17 KB638 KB17 KB199220252008Cacciapuoti, MarcoCozzani, EmanueleDescalzi Cancedda, FiorellaDi Marco, EddiParodi, AuroraZerega, Barbaraletnik:17številka:3str. 120-124ISSN:1318-4458COBISSID:24952025URN:URN:NBN:SI:doc-TCBPSLHHenSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et AdriaticaAntibodies, AntinucleardermatologijaFluorescenčno protitelo, tehnika indirektnaFluorescent Antibody Technique, IndirectGingivitis nekrotizirajoči, ulcerativniGingivitis, Necrotizing UlcerativeImmunoblottingImunoblotKeratinocitiKeratinocyteskožne bolezniLichen PlanusLihen planusprotitelesaProtitelesa protijedrnaPatients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa|Objective: The aim of this study is to verify whether stratified epithelium-specific antinuclear antibodies are present in the sera of patientswith erosive oral lichen planus and cutaneous lichen planus. Methods: We studied the pre-immune and immune serum of a rabbit immunized with a peptide corresponding to the N-terminus of the 70-kDa antigen chronic ulcerative stomatitis protein; sera from two patients, one with oral erosive lichen planus and one with cutaneous lichen planus who presented stratified epithelium-specific antinuclear antibodies at high titer; and a third serum from a patient with cutaneous lichen planus without stratified epithelium-specific antinuclear antibodies. Results: We demonstrated that the protein bands recognized by the serum of the rabbit immunized with an epitope of chronic ulcerative stomatitis protein co-migrated by SDS-PAGE with the protein bands recognized by the serum of a patient affected by oral erosive lichen planus and by the serum of a patient with cutaneous lichen planus, bothcontaining antibodies directed against a 70-kDa antigen. Conclusion: Our results confirm that antibodies specifically directed against the chronic ulcerative stomatitis protein are not a distinctive marker of chronic ulcerative stomatitis, but may also be detected in oral erosive and cutaneous lichen planusTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov