156 KB48 KB199420252003Štalc, JurijTominc, Urošštevilka:3letnik:42str. 229-242ISSN:0025-8121COBISSID:17452505URN:URN:NBN:SI:doc-TAQKVAMCslMedicinski razglediMedicinski razglediAneurysmAnevrizmaaterosklerozaBrachial ArteryBrahialna arterijaDrug EffectsEndotelij žilniEndothelium, VascularMagnetic Resonance ImagingMagnetna resonanca slikovnaožiljePopliteal ArteryPoplitealna arterijaUltrasonographyVasodilator AgentsVazodilatatorjižilni endotelijPrimerjava endotelijske funkcije in magnetoresonančnih lastnosti žilne stene med bolniki s klasično in dilatativno obliko ateroskleroze| Comparison of endothelial function and magnetic resonance characteristics of vessel wall among patients with classic and dilatative atherosclerosis|Background: Dilatative atherosclerosis is a rare form of degenerative process manifested by arterial aneurysms. It is believed that endothelial dysfunction is involved in dilatative atherosclerosis. For estimation of systemic endothelial dysfunction a standardized endothelium-dependent vasodilatation test can be used. Alteration of arterial wall in aneurysm can be visualized and estimated by high-resolution magnetic resonance imaging (MRI). Aim: The aim of our study was to compare endothelial function and some MRI structural and morphological characteristics of dilatative atherosclerosis. Hypotheses: 1. Endothelial function differs among groups. 2. MR signal from the vessel wall of popliteal aneurysm differs from that of atherosclerotic vessel wall. 3. MR signal from the vessel wall of popliteal aneurysm differs in comparison to the signal from nearby non-dilated site. 4. Thickness of the vessel wall atthe dilated (aneurysmal) site equals to the thickness of non-dilated site ofthe same vessel. Methods: We included 12 male patients with popliteal arteryaneurysm (group A) and 9 male patients with classic atherosclerosis (group K). Endothelial function was estimated by endothelium-dependent vasodilatation test. In all patients a high-resolution cross-section MRI through two standardized locations was made. The distal location was knee-joint fissure in group K or the widest section of the aneurysm in the group A. The proximal location was at least 6 cm proximally to the distal one in the group K or a non-dilated section of artery in the group A. The data taken from MR images (average intensity of the signal, standard deviation of the signal and geometrical characteristics of the vessel wall) was then statistically compared. Results: The comparisons of endothelium-dependent and endothelium-independent dilatation between groups showed no significant difference. (Abstract truncated at 2000 characters)Izhodišče: Zakaj pri nekaterih bolnikih prihaja do razširitev žil, pri drugih pa se žile zaradi intraluminal,nih plakov ožijo, ni jasno. Možno je, da gre zadve različni bolezni ali pa da se ateroskleroza zaradi še neznanih dejavnikov odraža na oba načina. Namen: S primerjavo funkcije endotelija, ocenjene s testom od endotelija odvisne in neodvisne vazodilatacije, za kateroje znano, da je pri aterosklerozi spremenjena, smo pri bolnikih s klasično in dilatativno obliko ateroskleroze želeli oceniti vpliv endotelija na nastanek anevrizem. Obenem smo s primerjavo žilne stene, ocenjene z magnetnoresonančnim slikanjem (MR), med bolniki s klasično in dilatativno aterosklerozo želeli odkriti morebitne morfološke ali strukturne značilnosti bolnikov z anevrizmami. Preiskovanci in metode: Vključili smo 12 moških z anevrizmo poplitealne arterije (skupina A) in 9 moških s klasično obliko ateroskleroze (skupina B). Sistemsko funkcijo endotelija smo ocenili s testom od endotelija odvisne in neodvisne vazodilatacije, strukturne in morfološke spremembe pa z MR poplitealne arterije na dveh nivojih. Rezultati: Primerjava od endotelija odvisne in neodvisne vazodilatacije med skupinama ni pokazala statistično značilnih razlik. Primerjava na maščobo normirane povprečne intenzitete signala žilne stene (NIS) ni pokazala statistično značilnih razlikniti znotraj skupine niti med skupinama. Našli smo razlike v normiranem standardnem odklonu intenzitete signala žilne stene (NSD), ki nam predstavlja merilo za homogenost signala žilne stene. V skupini A smo na mestu anevrizme našli pomembno zadebelitev. Zaključki: Pri bolnikih z anevrizmami perifernih arterij gre verjetno za enako okvaro endotelija kot pri bolnikih s klasično aterosklerozo. (Izvleček skrajšan pri 2000 znakih)TEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi