{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-SZZNAWXY/3eb36c43-e44c-43ef-8e11-a4b2aeed515a/PDF","dcterms:extent":"24922 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-SZZNAWXY/6ef7945d-6938-4973-9304-11ac0a20a055/TEXT","dcterms:extent":"0 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-SZZNAWXY","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:SPR-WQVGMCSC"},{"@xml:lang":"sl","#text":"Acta dermatovenerologica Alpina, Pannonica et Adriatica"}],"dcterms:issued":"2025","dc:creator":["Delaš Aždajić, Marija","Francesch, Nika","Mihalj, Martina","Pauzar, Biljana","Pauzar, Mirta","Plužarić, Vera","Rajc, Jasmina","Tolušić Levak, Maja"],"dc:contributor":"Mihalj, Martina","dc:format":[{"@xml:lang":"sl","#text":"letnik:34"},{"@xml:lang":"sl","#text":"številka:iss. 2"},{"@xml:lang":"sl","#text":"str. 51-54"}],"dc:identifier":["DOI:10.15570/actaapa.2025.14","ISSN:1318-4458","COBISSID_HOST:260270851","URN:URN:NBN:SI:doc-SZZNAWXY"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovene Welding Society"},"dc:subject":[{"@xml:lang":"en","#text":"immunoexpression"},{"@xml:lang":"sl","#text":"imunoekspresija"},{"@xml:lang":"en","#text":"inflammatory dermatoses"},{"@xml:lang":"en","#text":"interleukin-17"},{"@xml:lang":"sl","#text":"interlevkin-17"},{"@xml:lang":"en","#text":"lichen planus"},{"@xml:lang":"sl","#text":"vnetne dermatoze"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"Unraveling the role of IL-17 in lichen planus| a comparative investigation of clinical variability and immunopathogenic pathways|"},"dc:description":{"@xml:lang":"sl","#text":"Introduction: Lichen planus (LP) is a chronic T cell–mediated inflammatory disease affecting the skin and mucosa. Interleukin-17 (IL-17), a pro-inflammatory cytokine, has been implicated in LP pathogenesis, but its tissue-level expression across clinical variants remains underexplored. This study compares IL-17 expression in healthy skin and LP lesions and assesses variations based on clinical presentation. Methods: This cross-sectional retrospective study included 20 LP skin samples and 10 healthy controls. The sample collection spanned a period of 10 years. IL-17 expression was assessed via immunohistochemistry and quantified using a modified Q score. Samples were categorized by mucosal involvement and lesion distribution. Statistical analysis was performed with the MannWhitney U test. Results: IL-17 was absent in healthy skin but present in all LP samples. IL-17 expression was significantly higher in patients with both skin and oral mucosal involvement compared to those with cutaneous LP (p = 0.003). No significant difference was observed between generalized and localized LP. Conclusions: The results indicate a distinct increase in IL-17 expression in LP lesions, particularly with mucosal involvement, supporting its role in LP pathogenesis. These findings suggest IL-17 as a potential biomarker and therapeutic target, warranting further investigation in larger cohorts"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-SZZNAWXY","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-SZZNAWXY"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-SZZNAWXY/3eb36c43-e44c-43ef-8e11-a4b2aeed515a/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Združenje slovenskih dermatovenerologov"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-SZZNAWXY/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-SZZNAWXY"}}}}