{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-RX92W8EF/96bc4006-745f-4d8b-936d-1934d7a83141/PDF","dcterms:extent":"366 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-RX92W8EF/a9112319-8075-4554-89d8-6a5104d8b1e9/TEXT","dcterms:extent":"0 KB"}],"edm:TimeSpan":{"@rdf:about":"2010-2025","edm:begin":{"@xml:lang":"en","#text":"2010"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-RX92W8EF","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-UQS2GZJE"},{"@xml:lang":"sl","#text":"Slovenska pediatrija"}],"dcterms:issued":"2023","dc:creator":["Faganel Kotnik, Barbara","Jenko, Urša","Kitanovski, Lidija","Stefanović, Milica"],"dc:format":[{"@xml:lang":"sl","#text":"številka:3"},{"@xml:lang":"sl","#text":"letnik:30"},{"@xml:lang":"sl","#text":"str. 131-136"}],"dc:identifier":["DOI:10.38031/slovpediatr-2023-3-03","ISSN:1318-4423","COBISSID:173695747","URN:URN:NBN:SI:doc-RX92W8EF"],"dc:language":"sl","dc:publisher":[{"@xml:lang":"sl","#text":"Združenje pediatrov Slovenije"},{"@xml:lang":"sl","#text":"Združenje specialistov šolske in visokošolske medicine Slovenije"}],"dc:subject":[{"@xml:lang":"en","#text":"children"},{"@xml:lang":"sl","#text":"gliomi nizkega gradusa"},{"@xml:lang":"sl","#text":"inhibitorji MEK"},{"@xml:lang":"en","#text":"low-grade gliomas"},{"@xml:lang":"en","#text":"MEK inhibitors"},{"@xml:lang":"sl","#text":"otroci"},{"@xml:lang":"sl","#text":"tarčno zdravljenje"},{"@xml:lang":"en","#text":"targeted therapy"}],"dcterms:temporal":{"@rdf:resource":"2010-2025"},"dc:title":{"@xml:lang":"sl","#text":"Gliomi nizkega gradusa pri otrocih in zdravljenje z inhibitorji MEK| prikaz primera| Pediatric low-grade gliomas and MEK ingibitors| case report|"},"dc:description":[{"@xml:lang":"sl","#text":"Low-grade gliomas (LGG) are the most common primary tumours in the central nervous system in children. Histologically, they are a heterogeneous group of brain tumours. The most common of them is pilocytic astrocytoma. The signalling pathway of mitogen-activated protein kinase (MAPK) is involved in the pathogenesis of these tumours, so the search for effective targeted drugs with few side effects is the subject of current research. This article presents a clinical case of a boy with inoperable LGG, which was poorly responsive to established systemic treatment, so he received targeted treatment with an MEK inhibitor"},{"@xml:lang":"sl","#text":"Gliomi nizkega gradusa (angl. low-grade gliomas, LGG) so najpogostejši primarni tumorji v osrednjem živčnem sistemu pri otrocih. Histološko so heterogena skupina možganskih tumorjev. Najpogostejši med njimi je pilocitni astrocitom. V njihovo patogenezo je med drugim vpletena signalna pot proteinske kinaze, aktivirane z mitogenom (angl. mitogen-activated protein kinase, MAPK), zato je iskanje učinkovitih tarčnih zdravil z malo neželenimi učinki osrednji predmet trenutnih raziskav. V prispevku predstavljamo klinični primer dečka z neoperabilnim LGG, ki je bil slabo odziven na uveljavljene sistemske oblike zdravljenja, zato smo se odločili za tarčno zdravljenje z inhibitorjem MEK"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-RX92W8EF","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-RX92W8EF"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-RX92W8EF/96bc4006-745f-4d8b-936d-1934d7a83141/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo za pomoč otrokom s presnovnimi motnjami"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-RX92W8EF/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-RX92W8EF"}}}}