{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-QYDX6RX9/99399d42-3f72-441a-88e3-574a76e0a7de/PDF","dcterms:extent":"82 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-QYDX6RX9/3b398f56-c2cb-4771-8fd7-f18b1f68a15c/TEXT","dcterms:extent":"46 KB"}],"edm:TimeSpan":{"@rdf:about":"1994-2025","edm:begin":{"@xml:lang":"en","#text":"1994"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-QYDX6RX9","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-46R7GGHL"},{"@xml:lang":"sl","#text":"Medicinski razgledi"}],"dcterms:issued":"1999","dc:creator":"Dajčman, Davorin","dc:format":[{"@xml:lang":"sl","#text":"številka:2"},{"@xml:lang":"sl","#text":"letnik:38"},{"@xml:lang":"sl","#text":"str. 239-252"}],"dc:identifier":["ISSN:0025-8121","COBISSID:10799321","URN:URN:NBN:SI:doc-QYDX6RX9"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Medicinski razgledi"},"dc:subject":[{"@xml:lang":"sl","#text":"bolezni"},{"@xml:lang":"en","#text":"Cholangitis, sclerosing"},{"@xml:lang":"en","#text":"diagnostika"},{"@xml:lang":"en","#text":"disease"},{"@xml:lang":"sl","#text":"jetra"},{"@xml:lang":"en","#text":"therapy"},{"@xml:lang":"sl","#text":"vnetja"},{"@xml:lang":"sl","#text":"zdravljenje"},{"@xml:lang":"sl","#text":"žolčni vodi"},{"@rdf:resource":"http://www.wikidata.org/entity/Q9368"}],"dcterms:temporal":{"@rdf:resource":"1994-2025"},"dc:title":{"@xml:lang":"sl","#text":"Primarni sklerozantni holangitis| Primary sclerosing cholangitis|"},"dc:description":[{"@xml:lang":"sl","#text":"The aetiology and pathogenesis of the inflammatory and fibrotic bile duct lesions characteristic of primary sclerosing cholangitis is unknown, but several lines evidence support connection that genetic and immunologic factorsare involved. Disease is characterised by ongoing inflammation, destruction and fibrosis of intrahepatic and extrahepatic bile duct. Irreversible damage to the bile ducts leads cholestasis, cirrhosis and liver failure with premature death unless liver transplantation is performed. It is frequently associated with inflammatory bowel disease, usually ulcerative colbis. There is no satisfactory medical therapy for patients with primary sclerosing cholangitis. Lacking a specific remedy the goal of treatment is controlling inflammation and infection and to prevent scaring. Liver transplantation is treatment of choice in advanced liver disease"},{"@xml:lang":"sl","#text":"Izvleček. Etiologija in patogeneza vnetnega dogajanja in fibroze žolčnih vodovpri bolnikih s primarnim sklerozantnim holangitisom še ni pojasnjena. Obstajajo številni dokazi o tesni zvezi z genetskimi in imunskimi dejavniki. Za bolezen je značilno vnetje, propad in fibroza znotraj jetrnih in zunaj jetrnih žolčnih vodov. Trajna okvara žolčnih vodov vodi do holestaze, ciroze in odpovedi jeter, ki se brez presaditve jeter konča smrtno. Pogosto sovpada skroničnim vnetnim črevesnim obolenjem, najpogosteje z ulceroznim kolitisom. Še zmeraj ne poznamo zadovoljivega zdravijenja z zdravili, zato ostaja bistvo zdravljenja v obvladovanju vnetja, preprečevanju okužb in zaviranju brazgotinjenja. Izborno zdravljenje v napredovalih bolezenskih obdobjih je presaditev jeter"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-QYDX6RX9","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-QYDX6RX9"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-QYDX6RX9/99399d42-3f72-441a-88e3-574a76e0a7de/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo Medicinski razgledi"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-QYDX6RX9/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-QYDX6RX9"}}}}