{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-PQ8ZUM9G/43eb766f-68b7-436b-81e7-f3aa94298223/PDF","dcterms:extent":"505 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-PQ8ZUM9G/5a81086d-7f59-4913-a6f8-64c4a129fd47/TEXT","dcterms:extent":"24 KB"}],"edm:TimeSpan":{"@rdf:about":"2005-2025","edm:begin":{"@xml:lang":"en","#text":"2005"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-PQ8ZUM9G","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-8ER5ZBJN"},{"@xml:lang":"sl","#text":"Farmacevtski vestnik"}],"dcterms:issued":"2019","dc:creator":["Mravljak, Janez","Plesničar, Tjaša"],"dc:format":[{"@xml:lang":"sl","#text":"številka:3"},{"@xml:lang":"sl","#text":"letnik:70"},{"@xml:lang":"sl","#text":"str. 205-211"}],"dc:identifier":["ISSN:0014-8229","COBISSID_HOST:4765809","URN:URN:NBN:SI:doc-PQ8ZUM9G"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"biološki označevalci"},{"@xml:lang":"sl","#text":"izoprostani"},{"@xml:lang":"sl","#text":"nevroprostani"},{"@xml:lang":"sl","#text":"Oksidativni stres"},{"@xml:lang":"sl","#text":"preeklampsija"}],"dcterms:temporal":{"@rdf:resource":"2005-2025"},"dc:title":{"@xml:lang":"sl","#text":"Izoprostani in nevroprostani kot biološki označevalci oksidativnega stresa| Isoprostanes and neuroprostanes as biomarkers of oxidative stress|"},"dc:description":[{"@xml:lang":"sl","#text":"Oxidative stress is a state, when in favour of prooxidants, prooxidants and antioxidants become imbalanced. That happens when free radicals oxidize and destroy cell components. The main critical components being oxidized are lipids, from which isoprostanoids are released. Different series of isoprostanes are generated by free radical-induced peroxidation of arachidonic acid and series of neuroprostanes from docosahexaenoic acid located mainly in brain grey matter. Isoprostanes and neuroprostanes are considered biomarkers of oxidative stress in various diseases, such as central nervous system diseases, cancer, ishemia-reperfusion, genetic disorders, pre-clampsy, etc. That being said, isoprostanoids are not only produced by radical attacks, they are also biologically active compounds"},{"@xml:lang":"sl","#text":"Oksidativni stres je stanje, ki nastane zaradi neravnovesja med prooksidanti in antioksidanti v korist prvih. Reaktivni radikali so prooksidanti, ki reagirajo s celičnimi komponentami (jih oksidirajo) ter na njih povzročajo oksidativne poškodbe. Glavna tarča so večkrat nenasičene maščobne kisline v lipidih, iz katerih v nizu radikalskih reakcij nastanejo spojine, ki jih s skupnim izrazom imenujemo izoprostanoidi. Različne serije izoprostanov izvirajo iz arahidonske kisline fosfolipidnih molekul, serije nevroprostanov pa iz dokozaheksaenojske kisline, ki je večinoma v fosfolipidih sive možganovine. Izoprostani in nevroprostani so biološki označevalci oksidativnega stresa pri različnih boleznih, kot so bolezni centralnega živčnega sistema, rak, ishemija-reperfuzija, genetske nepravilnosti, preeklampsija itd. Izoprostanoidi niso le produkti oksidacije lipidov, ampak so tudi biološko aktivne spojine"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-PQ8ZUM9G","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-PQ8ZUM9G"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-PQ8ZUM9G/43eb766f-68b7-436b-81e7-f3aa94298223/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-PQ8ZUM9G/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-PQ8ZUM9G"}}}}