1121 KB35 KB200520252022Osel, NikaRoškar, Robertštevilka:3letnik:73str. 252-260ISSN:0014-8229COBISSID_HOST:115506947URN:URN:NBN:SI:doc-P9M7M3OYslSlovensko farmacevtsko društvoFarmacevtski vestnikanalizne tehnikeAntibiotikiMasna spektrometrijanestabilnostproteiniAnalizne tehnike za vrednotenje (ne)stabilnosti proteinov| Analytical techniques for evaluation of protein (in)stability|The discovery of antibiotics, the so-called »wonder drugs«, contributed significantly to the reduction of mortality rates and had a positive impact on medical progress. After the introduction of antibiotics, bacteria started to develop various mechanisms of resistance, and so increasing bacterial resistance to known antibacterial agents is a global problem in the 21st century. Bacteria can develop resistance to all known antimicrobials, and despite a large number of studies and many compounds in clinical trials, the need to discover new active ingredients and therapeutic approaches is growing. Compounds that inhibit multiple bacterial targets, known as multitarget ligands, are one of the strategies to fight bacterial resistance. Simultaneous inhibition of multiple targets in bacteria means that mutations leading to resistance should originate in several sites at the same time, which is less likely. Although multiple-acting compounds do not represent an absolute solution, they can contribute significantly to slowing down the emergence of resistant strainsOdkritje antibiotikov, ki jih včasih imenujemo kar »čudežna zdravila«, je močno pripomoglo k manjši smrtnosti in pozitivno vplivalo na medicinski napredek. V odgovor na rabo antibiotikov so bakterije razvile različne mehanizme odpornosti in tako naraščajoča bakterijska odpornost proti znanim protibakterijskim učinkovinam v 21. stoletju predstavlja globalni problem. Bakterije lahko razvijejo odpornost na vsa znana protimikrobna zdravila in kljub velikemu številu raziskav ter veliko spojinam v kliničnih preskušanjih je potreba po odkrivanju novih učinkovin in terapevtskih pristopov vedno večja. Spojine, ki zavirajo več bakterijskih tarč, multitarčni ligandi, so ena od strategij boja z bakterijsko odpornostjo. Simultano zaviranje več tarč v bakteriji namreč pomeni, da bi mutacije za pridobitev odpornosti morale poteči na več mestih hkrati, kar je manj verjetno. Četudi spojine z multiplim delovanjem ne predstavljajo absolutne rešitve, pa lahko znatno pripomorejo k upočasnitvi pojava odpornih sevovTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo