572 KB0 KB199820252023Gobec, StanislavGrošelj, UrošGršič, MarijaJukič, MarkoKnez, DamijanMeden, AnžeSvete, Jurijštevilka:4letnik:70str. 545-559DOI:10.17344/acsi.2023.8460ISSN:1580-3155COBISSID:179806979URN:URN:NBN:SI:doc-OYWGI3N8enSlovensko kemijsko društvoActa chimica slovenica1,1’-Carbonyldiimidazole (CDI)1,1’-karbonildiim-idazol (CDI)amidacijeamidationscatalytic hydrogenationcholinesterase (ChE) inhibitorsderivati indoladerivati triptofanaindole derivativeskatalitsko hidrogeniranjeprerazporeditverearrangementstryptophan derivativeszaviralci holinesteraze (ChE)Synthesis and cholinesterase inhibitory activity of selected indole-based compounds|Synthesis and anticholinesterase activity of 18 previously unpublished indole- and tryptophan-derived compounds are disclosed. These compounds containing an indole structural unit exhibit selective submicromolar inhibition of human butyrylcholinesterase (hBChE). The structures of the newly synthesized compounds were confirmed by ?$^1H$? and ?$^{13}NMR$?1H, IR spectroscopy, and high-resolution mass spectrometryV članku je opisana sinteza in antiholinesterazna aktivnost 18 doslej neobjavljenih spojin, derivatov indola in triptofana. Spojine, ki vsebujejo indolni strukturni fragment, izkazujejo selektivno submikromolarno zaviranje človeške butirilholin esteraze (hBChE). Strukture na novo sintetiziranih spojin so bile potrjene z ?$^1H$? and ?$^{13} NMR$?1H, IR spektroskopijo in masno spektrometrijo visoke ločljivostiTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko kemijsko društvo