175 KB27 KB200520252018Bogataj, MarijaFelicijan, Tjašaštevilka:2letnik:69str. 75-80ISSN:0014-8229COBISSID_HOST:4505969URN:URN:NBN:SI:doc-OOIPP5C1slSlovensko farmacevtsko društvoFarmacevtski vestnikbiofarmacevtski procesifarmakokinetične interakcijeFarmakokinetikaHranainterakcije hrana-zdravilaprebavni traktBiofarmacevtski vidiki interakcij med hrano in zdravili| Biopharmaceutical aspects of food-drug interactions|Interactions between food and drugs can be divided into pharmacodynamic interactions which are based on the mechanism of action of the drug, and pharmacokinetic interactions based on the processes of drug dissolution, absorption, distribution, metabolism, and elimination. The emphasis of the present article is on the influence of food on the above-mentioned biopharmaceutical processes. We focused at the presystemic level where food-drug interactions occur frequently due to the direct contact between food and drug delivery systems. Changes in the characteristics of the media in the lumen and changes in transit times along the gastrointestinal tract are described, as well as other influences, such as the impact on active transport and first-pass metabolism. Influences on systemic biopharmaceutical processes can also be very important but are less frequent. Clinically important drug food interactions which frequently appear in all described groups have to be anticipated, and in spreorder to prevent such interactions, appropriate measures should be takenInterakcije med hrano in zdravili delimo na farmakodinamske, do katerih prihaja na nivoju mehanizma delovanja zdravilnih učinkovin in farmakokinetične, ki potekajo na nivoju procesov sproščanja, absorpcije, porazdelitve, metabolizma in izločanja. Poudarek pregleda v tem članku je na vplivih hrane na zgoraj navedene biofarmacevtske procese, še posebej na predsistemskem nivoju, kjer so, zaradi direktnega kontakta med hrano in zdravili, interakcije najbolj pogoste. Opisane so spremembe v lastnostih medijev v lumnu prebavnega trakta, v časih prehodov skozi prebavni trakt, in drugi vplivi, kot so vplivi na aktivni transport in predsistemski metabolizem. Tudi vplivi na sistemske biofarmacevtske procese so lahko zelo pomembni, vendar so redkejši. V vseh skupinah interakcij so pogoste klinično pomembne interakcije, ki jih je potrebno vnaprej predvideti in sprejeti ustrezne ukrepe, da jih preprečimoTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo