292 KB34 KB199220252006Kazanowska, BernardaReich, AdamWróbel, Grazynaletnik:15številka:4str. 158-168ISSN:1318-4458COBISSID_HOST:22327257URN:URN:NBN:SI:doc-NRZOZDJ2enSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et AdriaticaDiagnosisKožne manifestacijeKožne novotvorbeLymphoma, Non-Hodgkin'sNeoplasm StagingNovotvorba, stadijPathologyPreživetje, analizaRetrospective StudiesRetrospektivne študijeSkin ManifestationsSkin NeoplasmsSurvival AnalysisTherapySkin involvement in highly malignant non-Hodgkin lymphomas of childhood and adolescence|Objective: The aim of this study was to demonstrate the clinical spectrum of highly malignant cutaneous non-Hodgkin lymphoma (NHL) in children and to define the outcome among these patients. Material and methods: A retrospectiveanalysis of children with NHL treated at Polish oncology centers was carried out in order to determine patients with skin involvement. Thirteensubjects with primary and 4 with secondary cutaneous NHL were studied.The diagnosis of NHL was based on histological and immunohistochemicalexamination of skin biopsy. Results: Nine of 13 cases of primary cutaneous NHL presented as a tumors. Other manifestations were as follows: hard infiltration, edema of subcutaneous tissue, maculopapular lesions, and generalized erythroderma. The mean time between the first cutaneous symptoms and diagnosis of NHL was 5.6 +_ 3.3 months. Secondary cutaneous lesions during the course of NHL were described as maculopapular or nodular eruption. In addition, 2 subjects had generalized ichthyosis. Among patients with primary cutaneous NHL, 11 (84.6%) subjects are still alive without any signs of the disease. Two children (15.4°/o) died. In patients with secondary skin involvement during the course of NHL only one child is still alive with a residual tumor mass in the mediastinum. The estimated 5-year overall survival for primary cutaneous NHL was significantly better than for individuals with secondary cutaneous NHL (p = 0.02). Conclusions: Primary cutaneous NHL has a relatively favorable prognosis. On the other hand,cutaneous metastases of extracutaneous NHL seem to be a poor prognostic factorTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov