155 KB14 KB199420252000Štiblar-Martinčič, Dragaštevilka:1letnik:39str. 79-83ISSN:0025-8121COBISSID:11475161URN:URN:NBN:SI:doc-NE9SRMXBslMedicinski razglediMedicinski razglediAntigen-presenting cellsBone marrowcitologijaCytoplasmic granulesEpidermisHematoxylinImmunologyLangerhans cellsLangerhansove celiceMacrophagesMicroscopy, electronmorfologijaT-lymphocytesUltrastructureMorfološke značilnosti Langerhansovih celic| Morphological characteristics of Langerhans cells|Langerhans cells are part of the widely distributed antigen-presenting cells known as dendritic cells with a key role in immune responses. These specialised bone marrow-derived cells were originally found in the epidermis and later demonstrated in the mucosa of other organs. Langerhans cells are difficult to identifiy in sections stained with hematoxylin-eosin. A large number of surface and/or cytoplasmic antigens have been localised on Langerhans cells for immunohistochemical detection. The Birbeck granules are the specific markers of Langerhans cells on electron microscopical level. Langerhans cells represent the primary immune defence of the skin and mucosae with various immunological functions, among which the processing and presenting antigen to T lymphocytes are the most importantLangerhansove celice so del obsežnega sistema antigen predstavitvenih celic, znanih pod imenom dendritične celice, ki imajo osrednjo vlogo pri imunskem odzivu. Prvotno so te specializirane celice, ki imajo izvor v kostnem mozgu, našli v povrhnjici, kasneje pa so jih prikazali tudi v sluznici različnih organov. V preparatih, obarvanih s hematoksilinom in eozinom, so Langerhansovecelice v svetlobnem mikroskopu težje prepoznavne, dokažemo pa jihimunohistokemično na osnovi številnih površinskih in/ali citoplazmatskih antigenov. Specifičen označevalec za prepoznavo na elektronskomikroskopski ravni so Birbeckova zrnca. Langerhansove celice omogočajo primarno predelavo in predstavitev antigena limfocitom T v koži in sluznicahTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi