806 KB27 KB202220252024Kočivnik, Ninaštevilka:3str. 4-8COBISSID_HOST:208844803ISSN:2820-5014URN:URN:NBN:SI:doc-N6XR2P7NslFakulteta za farmacijo, ŠSSFDPlaceboAlzheimerjeva bolezenamiotrofična lateralna sklerozaHuntingtonova bolezenNevrodegenerativne bolezniParkinsonova bolezenSplošni pregled nevrodegenerativnih bolezni|Neurodegenerative diseases are a heterogeneous group of diseases characterised by gradual loss of nerve cells which consequently shows as the degeneration of various parts of the nervous system. The extent of neuronal loss is usually related to the occurrence and progression of disease-specific clinical symptoms. The most common neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and Huntington's disease, which are discussed in detail in this review. Neurodegenerative diseases are permanent and incurable. Although several medications are currently approved for their treatment, most of them only alleviate the symptoms. Therefore, several studies are currently being conducted with the aim to understand mechanisms of these diseases, which could lead to the development of effective therapies for their treatmentNevrodegenerativne bolezni predstavljajo heterogeno skupino obolenj, za katera je značilna postopna izguba nevronov, kar se odraža z degeneracijo različnih delov živčnega sistema. Stopnja izgube nevronov je običajno neposredno povezana s pojavom in napredovanjem kliničnih simptomov, ki so specifični za posamezne bolezni. Med najpogostejšimi nevrodegenerativnimi boleznimi so Alzheimerjeva bolezen, Parkinsonova bolezen, amiotrofična lateralna skleroza in Huntingtonova bolezen, ki so v tem pregledu podrobneje obravnavane. Nevrodegenerativne bolezni so trajne in neozdravljive. Čeprav je trenutno odobrenih več zdravil za njihovo zdravljenje, jih večina le blaži spremljajoče simptome. Zato so v teku številne študije, usmerjene v razumevanje mehanizmov teh bolezni, kar bi lahko privedlo do razvoja učinkovitih terapij za njihovo obvladovanjeTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of Slovenia