617 KB0 KB199220252025Abd El-Raheem, Talal A.Hassan, MohammedKamal, Hagar AliShake, Olfat G.Soliman, Amira E.Yaseen, Sara M.Yaseen, Sara M.letnik:34številka:iss. 2str. 45-49DOI:10.15570/actaapa.2025.13ISSN:1318-4458COBISSID_HOST:260272387URN:URN:NBN:SI:doc-MRB21694enSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et Adriaticaautoimmune diseaseavtoiminska bolezencitokinicytokinesELISAIL-39luskavicapsoriasisDetection of serum and tissue levels of interleukin 39 in psoriasis| a case control study|Introduction: Psoriasis is a chronic immune-mediated disorder with a genetic component that primarily affects the skin and has potential systemic involvement. Advances in understanding the interaction between the innate and adaptive immune systems have facilitated improved disease management. Methods: This study included 25 patients with psoriasis and 20 healthy controls of both sexes. All participants underwent detailed medical history-taking and dermatological examination, including assessment of the body surface area and the Psoriasis Area and Severity Index (PASI). Blood samples (3 ml) were collected from all subjects, and 4 mm lesional skin punch biopsies were obtained from psoriatic patients and healthy controls. Results: Serum and tissue levels of interleukin 39 (IL-39) were significantly elevated in psoriatic patients compared to healthy individuals. Patients with a positive family history of psoriasis showed higher serum IL-39 levels than those without such a history. In addition, psoriatic individuals with diabetes mellitus or hypertension had higher serum IL-39 levels than those without these comorbidities. A statistically significant correlation was found between disease severity and serum IL-39 concentration. Conclusions: Elevated serum and tissue IL-39 levels in psoriatic patients suggest a potential role for IL-39 in the pathogenesis of psoriasis, highlighting its possible utility as a biomarker or therapeutic targetTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov