4562 KB42 KB200520252021Zvonar Pobirk, Alenkaštevilka:4letnik:72str. 231-241ISSN:0014-8229COBISSID:76995331URN:URN:NBN:SI:doc-MLDGQF9VslSlovensko farmacevtsko društvoFarmacevtski vestnikbarierna funkcijadiferenciacija keratinocitovKožalipidipH kožePomen barierne funkcije za zdravje naše kože| The skin health and the role of epidermal barrier function|The skin is our largest organ, fulfiling different functions. It serves as our primary defence sytem, regulating the exchange of substances with surounding environment and protecting our body from various external factors. Effective epidermal barrier, which is cruical for the health of the skin and the entire body, resides predominantly (around 90 %) in the outermost skin layer - stratum corneum. The stratum corneum with its interconnected corneocyte embedded in a cornified envelope, and intercellular highly structured lipid bilayers largely controls the transcutaneous absorption of xenobiotics and regulates the transcutaneous water loss through the skin surface. Herein the mechanisms involved in barrier homeostasis regulation are presented, together with some disorders increasing the risk for the development of various (inflammatory) skin diseases. Selected non-invasive methods suitable for n vivo monitoring of various skin parameters related to skin barrier function are presented briefly. They found their use in early diagnosis and monitoring of the therapy effectiveness, and have important role in the development and efficacy evaluation of new dermal productsKoža je naš največji organ, ki opravlja številne funckije. Uravnava tudi izmenjavo snovi z okoljem in nas ščiti pred različnimi zunanjimi dejavniki. Učinkovita bariera, h kateri približno 90 % prispeva najbolj zunanja plast kože - rožena plast, je tako bistvena za zdravje ne le kože temveč celotnega telesa. Rožena plast z medsebojno povezanimi korneociti, njihovo poroženelo ovojnico in intercelularnimi visoko urejenimi lipidnimi dvosloji nadzoruje transdermalno absorpcijo ksenobiotikov in nas ščiti pred prekomerno izgubo vode skozi kožo. V prispevku so predstavljeni mehanizmi, ki sodelujejo pri vzdrževanju homeostaze kožne bariere, pa tudi nekatere motnje, ki lahko vodijo v razvoj različnih (vnetnih) obolenj kože. Na kratko so predstavljene tudi izbrane neinvazivne metode, ki omogočajo vrednotenje različnih, za barierno funkcijo kože pomembnih, parametrov kože in vivo. Tako omogočajo hitro diagnostiko in spremljanje učinkovitosti zdravljenja ali nege in imajo pomembno vlogo v razvoju in vrednotenju učinkovitosti novih dermatikov in izdelkov za nego kožeTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo