2102 KB10 KB199220251998Belič, MirjamBowden, Paul E.Dolenc-Voljč, MatejaKansky, Aleksejštevilka:3/4letnik:7str. 135-138ISSN:1318-4458COBISSID:8099289URN:URN:NBN:SI:doc-LWBAZ0RSenSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et AdriaticaAspergillusCandidaCongenitaldermatologijaDiagnosisIsolation and purificationKeratosiskožne boleznimikozeMycosesNail diseasesnohtiRhodotorulaTrichophytonMycological examination in pachyonychia congenita|Introduction. Pachyonychia congenita (PC) is a hereditary disorder of keratinization characterized by extremely thickened nails, follicular hyperkeratosis, insular palmoplantar keratoderma and thickened, whitish lingual and buccal mucosa sometimes involving also gingivae. It was established during the last few years that this disorder is due to mutations of keratin genes. The additional role of yeasts in the pathogenesis of PC was sometimes questioned, however no systemic study could be traced in the literature. Methods. mycologic investigations of nails and insular keratoses were carried out in eight Slovenian patients with PC-1: direct microscopy and cultivation on Sabouraud's dextrose agar. In all these patients the keratin mutations had been defined. Results. Candida species (Cand sp) were isolated from fingernails in two and Aspergillus sp in another patient. From toenails Cand sp was isolated in 2 and Rodotorula sp in another patient. From the keratinous material from the soles Trinchophyton mentagrophytes was isolated in two patients and Cand sp in another. Conclusion. Detection of Cand sp, Aspergillus sp or Rodotorula sp, spores in just a few patients is considered to be an accompanying phenomenonTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov