{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-LOXL70AY/f290ed49-a34e-442b-86bf-e3e1bcd1e578/PDF","dcterms:extent":"217 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-LOXL70AY/0f1ee945-f7a0-42a1-bf3d-865825bdd49d/TEXT","dcterms:extent":"16 KB"}],"edm:TimeSpan":{"@rdf:about":"2002-2024","edm:begin":{"@xml:lang":"en","#text":"2002"},"edm:end":{"@xml:lang":"en","#text":"2024"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-LOXL70AY","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-1R5DVDOA"},{"@xml:lang":"sl","#text":"Informatica Medica Slovenica"}],"dcterms:issued":"2006","dc:creator":"Stojan, Jure","dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:11"},{"@xml:lang":"sl","#text":"str. 60-65"}],"dc:identifier":["ISSN:1318-2129","COBISSID:21479129","URN:URN:NBN:SI:doc-LOXL70AY"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko društvo za medicinsko informatiko"},"dc:subject":[{"@xml:lang":"sl","#text":"biokemija"},{"@xml:lang":"sl","#text":"encimska kinetika"},{"@xml:lang":"sl","#text":"molekularna biologija"},{"@xml:lang":"sl","#text":"molekularno modeliranje"}],"dcterms:temporal":{"@rdf:resource":"2002-2024"},"dc:title":{"@xml:lang":"sl","#text":"Encimska kinetika in molekularno modeliranje se dopolnjujeta pri proučevanju reakcijskih mehanizmov| Enzyme kinetics and molecular modeling complement each other at study of reaction mechanisms|"},"dc:description":[{"@xml:lang":"sl","#text":"The kinetics of cholinesterases is complex and show several deviations from classical Micaelis-Menten hyperbola. Therefore, we tried to correlate the results of kinetic measurements with available crystallographic data and suggest an appropriate reaction scheme for the hydrolysis of acetylthiocholine- an artificial chromogenic substrate. By means of molecular modeling we anticipated important reaction intermediates and suggested steric hindrance of deacetylation as a basis for the inhibition by the excess of substrate"},{"@xml:lang":"sl","#text":"Kinetika holinesteraz je zelo zapletena in kaže več odstopanj od klasične MichaelisMentenove hiperbole. Zato smo želeh uskladiti rezultate kinetičnih meritev z znanimi kristalografskimi podatki in tako predlagati reakcijsko shemo hidroliti~ne pretvorbe acetiltiohohna - umetnega kromogenega substrata. S pomočjo molekularnega modeliranja smo prikazali pomembne vmesne produkte v reakcijskem mehanizmu in s steričnim oviranjem deacetilacije razložili inhibicijo holinesteraze s prebitkom substrata"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-LOXL70AY","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-LOXL70AY"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-LOXL70AY/f290ed49-a34e-442b-86bf-e3e1bcd1e578/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko društvo za medicinsko informatiko"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-LOXL70AY/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-LOXL70AY"}}}}