32 KB183 KB30 KB200520252005Byrne Habič, BarbaraMravljak, JanezPečar, Slavkoštevilka:1letnik:566 stranistr. 11-16ISSN:0014-8229COBISSID:1722993URN:URN:NBN:SI:doc-L9D4RKJXslSlovensko farmacevtsko društvoFarmacevtski vestnikbiokemijadušikov oksidDušikov oksid II: biološki učinki in učinkovine, ki sproščajo NO|Nitric oxide, as a key mediator in many physiological and pathophysiological processes, expresses most of its biological effects by activation of soluble guanylyl cyclase. In some illnesses it is therapeutically desirable to increase its concentration, in others to inhibit its excessive formation. Appart from organic nitrates that have been used in therapy for several years, new NO donors with different mechanisms of dissociation and selective effects in other target effector systems and tissues have more recently been testedDušikov oksid, kot ključni prenašalec v številnih fizioloških in patofizioloških procesih, izraža večino bioloških učinkov preko aktivacije topne gvanilat ciklaze. Pri posameznih obolenjih je terapevtsko ugodno bodisi povečanje njegove koncentracije, ali pa zaviranje njegove prekomerne tvorbe. Poleg organskih nitratov, ki so v terapiji že vrsto let, preizkušajo nove NO-donorje z drugačnim mehanizmom sproščanja in učinki tudi na druge tarčne efektorske sisteme in tkivaTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo