384 KB40 KB199220252013Glavač, DamjanHauptman, Ninaštevilka:4letnik:47str. 311-318, IISSN:1318-2099COBISSID:30890969URN:URN:NBN:SI:doc-KVKF6SQIenAssociation of Radiology and OncologyRadiology and oncology (Ljubljana)biomarkerbiomarkerjidiagnostikadolge nekodirane RNA molekulelong non-coding RNAsmicroRNAsrak (medicina)MicroRNAs and long non-coding RNAs| prospects in diagnostics and therapy of cancer|Background. Non-coding RNAs (ncRNAs) are key regulatory molecules in cellular processes, and are potentialbiomarkers in many diseases. Currently, microRNAs and long non-coding RNAs are being pursued as diagnostic andprognostic biomarkers, and as therapeutic tools in cancer, since their expression profiling is able to distinguish differentcancer types and classify their sub-types.Conclusions. There are numerous studies confirming involvement of ncRNAs in cancer initiation, development andprogression, but have only been recently identified as new diagnostic and prognostic tools. This can be beneficialin future medical cancer treatment options, since ncRNAs are natural antisense interactors included in regulationof many genes connected to survival and proliferation. Research is directed in development of useful markers fordiagnosis and prognosis in cancer and in developing new RNA-based cancer therapies, of which some are alreadyin clinical trialsTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo radiologije in onkologije