{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-KU0KIXSI/73a-1a09431682ccef-938a014-0e-2547bb/PDF","dcterms:extent":"1317 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-KU0KIXSI/405840ba-0ac7-4921-a738-e31c2b369e1f/TEXT","dcterms:extent":"24 KB"}],"edm:TimeSpan":{"@rdf:about":"2022-2025","edm:begin":{"@xml:lang":"en","#text":"2022"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-KU0KIXSI","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-UCB4A42Q"},{"@xml:lang":"sl","#text":"Placebo"}],"dcterms:issued":"2022","dc:creator":["Frlic, Tjaša","Korbar, Karmen"],"dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"str. 26-30"}],"dc:identifier":["COBISSID_HOST:122888963","ISSN:2820-5014","URN:URN:NBN:SI:doc-KU0KIXSI"],"dc:language":["en","sl"],"dc:publisher":{"@xml:lang":"sl","#text":"Fakulteta za farmacijo, ŠSSFD"},"dc:subject":[{"@xml:lang":"en","#text":"autoantibodies"},{"@xml:lang":"sl","#text":"Avtoimunske bolezni"},{"@xml:lang":"sl","#text":"avtoprotitelesa"},{"@xml:lang":"en","#text":"complete blood count"},{"@xml:lang":"sl","#text":"ELISA"},{"@xml:lang":"sl","#text":"encimsko-imunokemijske metode"},{"@xml:lang":"en","#text":"enzyme immunochemical methods"},{"@xml:lang":"en","#text":"indirect immunofluorescence"},{"@xml:lang":"sl","#text":"indirektna imunofluorescenca"},{"@xml:lang":"en","#text":"inflammatory markers"},{"@xml:lang":"sl","#text":"krvna slika"},{"@xml:lang":"sl","#text":"Laboratorijske preiskave"},{"@xml:lang":"sl","#text":"označevalci vnetja"},{"@xml:lang":"sl","#text":"Revmatične bolezni"}],"dcterms:temporal":{"@rdf:resource":"2022-2025"},"dc:title":{"@xml:lang":"sl","#text":"Laboratorijske preiskave za odkrivanje revmatičnih bolezni avtoimunskega izvora|"},"dc:description":[{"@xml:lang":"sl","#text":"Disorders are part of rheumatic diseases with predominant inflammation and/or autoimmune signs. Autoimmune diseases are very complex and there is not one specific test that can diagnose autoimmune disease conclusively. Testing of mentioned diseases usually starts with basic hematological and biochemical tests. Important tests are hemogram and biochemical test for inflammatory biomarkers, especially sedimentation and C-reactive protein (CRP). With them we can confirm presence of inflammatory process in patient’s body, which is characteristic for reumatic autoimmune diseases. Next test performed is usually test on HEp-2 cells, that is based on indirect immufluorescence. This is a reference method for detection of antinuclear antibodies. Furthermore, enzyme immunochemical methods are mostly used for quantification of specific autoantibodies. Some of them are specific for one disease, but interpretation of test results is by most of them very complicated. During the diagnosis, it is important to consider clinical status of the patient as well"},{"@xml:lang":"sl","#text":"Vnetne revmatične bolezni in sistemske bolezni vezivnega tkiva sta skupini revmatskih bolezni, kjer prevladuje vnetje in/ali avtoimunsko dogajanje. Avtoimunske bolezni so zelo kompleksne bolezni, zato ne obstaja samo en test, s katerim bi lahko podali diagnozo. Laboratorijsko testiranje zgoraj omenjenih bolezni se običajno začne z osnovnimi hematološkimi in biokemijskimi preiskavami. Pomembna testa sta hemogram in določanje označevalcev vnetja, predvsem sedimentacije in C-reaktivnega proteina (CRP), s katerimi potrdimo prisotnost vnetnega procesa v telesu, ki je značilen za revmatske avtoimunske bolezni. Pri sumu na avtoimunsko bolezen sledi presejalni test HEp-2, katerega osnova je indirektna imunofluorescenca in je referenčna metoda za določanje protiteles proti znotrajceličnim antigenom jedra, citoplazme in celice v delitvi. Sledi diferencialna diagnostika, kjer se določajo specifična avtoprotitelesa, predvsem z encimsko-imunokemijskimi metodami. Nekatera avtoprotitelesa so značilna za določeno bolezen, vendar je pri večini avtoimunskih bolezni interpretacija rezultatov testov zelo zapletena. Poleg njih je treba vselej spremljati tudi klinično sliko bolnika"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-KU0KIXSI","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-KU0KIXSI"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-KU0KIXSI/73a-1a09431682ccef-938a014-0e-2547bb/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:dataProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-KU0KIXSI/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-KU0KIXSI"}}}}