{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-KTS8RJS4/ff03d23a-c070-4c8a-95f3-e6008fa59cff/PDF","dcterms:extent":"195 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-KTS8RJS4/bbd33dba-e2c0-49b8-b5d6-8a3f80945252/TEXT","dcterms:extent":"21 KB"}],"edm:TimeSpan":{"@rdf:about":"2005-2025","edm:begin":{"@xml:lang":"en","#text":"2005"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-KTS8RJS4","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-8ER5ZBJN"},{"@xml:lang":"sl","#text":"Farmacevtski vestnik"}],"dcterms:issued":"2016","dc:creator":["Avsec, Damjan","Flegar, Ines"],"dc:format":[{"@xml:lang":"sl","#text":"številka:6"},{"@xml:lang":"sl","#text":"letnik:67"},{"@xml:lang":"sl","#text":"str. 374-379"}],"dc:identifier":["ISSN:0014-8229","COBISSID_HOST:30044711","URN:URN:NBN:SI:doc-KTS8RJS4"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"gensko zdravljenje"},{"@xml:lang":"sl","#text":"Huntingtonova horea"},{"@xml:lang":"sl","#text":"proteini z domeno cinkovega prsta"},{"@xml:lang":"sl","#text":"protismiselni oligonukleotid"},{"@xml:lang":"sl","#text":"RNA-interferenca"},{"@rdf:resource":"http://www.wikidata.org/entity/Q213901"}],"dcterms:temporal":{"@rdf:resource":"2005-2025"},"dc:title":{"@xml:lang":"sl","#text":"Gensko zdravljenje Huntingtonove bolezni| Gene therapy for Huntington's disease|"},"dc:description":[{"@xml:lang":"sl","#text":"Huntington's disease is a rare, incurable neurodegenerative disease of the central nervous system caused by the mutation in the HTT gene. Currently, there is no treatment that can cure or slow the course of Huntington's disease, so the treatment is aimed at ameliorating symptoms. Gene therapy is a promising new approach that targets the cause of Huntington's disease. Insertion of neuroprotective genes, gene silencing, and genome editing technologies are being investigated in the hope of proving effective in stopping progression of the disease. The article focuses on principles of this new approaches and presents the current state of development of gene therapy for Huntington's disease"},{"@xml:lang":"sl","#text":"Huntingtonova bolezen je redka neozdravljiva nevrodegenerativna bolezen centralnega živčevja, ki jo povzroča mutacija v genu za huntingtin (HTT). Trenutno nimamo zdravila, ki bi ozdravilo ali upočasnilo potek bolezni, zato je zdravljenje večinoma simptomatsko. Gensko zdravljenje predstavlja nov pristop, ki cilja vzrok za nastanek te bolezni. Preučujejo vnos nevroprotektivnih genov ter tehnologije utišanja genov in urejanja genoma v upanju, da bodo ti pristopi upočasnili napredovanje bolezni. Članek se osredotoča na principe teh novih pristopov in podaja trenutno stanje razvoja genskega zdravljenja pri Huntingtonovi bolezni"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-KTS8RJS4","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-KTS8RJS4"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-KTS8RJS4/ff03d23a-c070-4c8a-95f3-e6008fa59cff/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-KTS8RJS4/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-KTS8RJS4"}}}}