81 KB31 KB199420251997Golmajer, Peterštevilka:2letnik:36str. 167-180ISSN:0025-8121COBISSID:7908057URN:URN:NBN:SI:doc-K3IZXIDOslMedicinski razglediMedicinski razglediBiopsyDiagnosisdiagnostikaDysplastic nevus syndromekožni rakmelanomMelanomaMicroscopyNevus, pigmentedPathologySkin neoplasmsZgodnje odkrivanje maligne alteracije pigmentnih znamenj| Early detection of pigmented nevi malignant alteration|Malignant melanoma is a highly malignant tumor, and its response to treatment is poor. Its incidence is on an increase world-wide. Amplified surface microscopy is a riew non-invasive diagnostic method enabling the detection of atypical (dysplastic) nevi, which are frequent precursors of malignant melanoma, as well as of signs that indicate the initial symptoms of malignant afteration much earlier than it used to be possible by a standard clinical examination. Therefore, our study was aimed at establishing the reliability and accuracy of amplified surface microscopy in comparison with standard dinical examination. The investigated group consisted of 41 individuals eithermeeting the criteria for clinical diagnosis of atypical nevus or malignant melanoma, or presenting with at least one cleary exoressed indicatorfor atypical nevus. The suspidous nevi were afterwards also examined by amplified surface microscopy and the results compared to the histological findings. It has been found that amplified surface microscopy is better and more reliable than clinical examination. This finding has been statistically confirmed; the degree of risk was less than 1 %Maligni melanom je zelo maligen tumor, rezultati zdravljenja pa so slabi. Povsod po svetu je njegova pojavnost v porastu. Svetlobno površinska mikroskopija je nova, neinvazivna diagnostična metoda, ki omogoča razpoznavo atipičnih (displastibnih) nevusov, ki so pogosti prekurzorji malignega melanoma, in znamenj, ki že kažejo najzgodnejše znake maligne alteracije mnogoprej kot običajni klinični pregled. Glavni namen raziskave je bil torej ugotoviti zanesljivost in natančnost svetlobno površinske mikroskopije v primerjavi z dosedanjim kliničnim pregledom. V raziskavo je bilo vkljubenih 41preiskovancev, ki so izpolnjevali kriterije za klinično diagnozo atipični nevus, maligni melanom, ali pa je bil vsaj eden izmed kriterijev za atipični nevus močno izražen. Sumljiva znamenja smo pregledali nato še s površinskim svetlobnim mikroskopom in rezultate primerjali s histološkimi izvidi. Raziskava je pokazala, da je svetlobno površinska mikroskopija boljša in zanesljivejša metoda kot klinični pregled. To smo statistično potrdili z manj kot 1% stopnjo tveganjaTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi