{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-JEN8WMND/03e0fbab-8b63-42d4-ba34-78dd4b639333/PDF","dcterms:extent":"1266 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-JEN8WMND/82ae0303-5e14-45dd-8de1-b642da9f0a2b/TEXT","dcterms:extent":"39 KB"}],"edm:TimeSpan":{"@rdf:about":"2008-2025","edm:begin":{"@xml:lang":"en","#text":"2008"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-JEN8WMND","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-YR600LYC"},{"@xml:lang":"sl","#text":"Acta medico-biotechnica"}],"dcterms:issued":"2013","dc:creator":["Dolenšek, Jurij","Rupnik, Marjan","Skelin, Maša","Stožer, Andraž"],"dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:6"},{"@xml:lang":"sl","#text":"str. 20-32"}],"dc:identifier":["ISSN:1855-5640","COBISSID:512298296","URN:URN:NBN:SI:doc-JEN8WMND"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Medicinska fakulteta"},"dc:subject":[{"@xml:lang":"en","#text":"beta cell"},{"@xml:lang":"en","#text":"calcium dye"},{"@xml:lang":"sl","#text":"celica beta"},{"@xml:lang":"en","#text":"confocal fluorescent microscopy"},{"@xml:lang":"en","#text":"electrophysiology"},{"@xml:lang":"sl","#text":"elektrofiziologija"},{"@xml:lang":"en","#text":"graph theory"},{"@xml:lang":"en","#text":"islet of Langerhans"},{"@xml:lang":"sl","#text":"kalcijevo barvilo"},{"@xml:lang":"sl","#text":"konfokalna fluorescenčna mikroskopija"},{"@xml:lang":"sl","#text":"Langerhansov otoček"},{"@xml:lang":"en","#text":"mouse pancreatic tissue slice"},{"@xml:lang":"sl","#text":"teorija grafov"},{"@xml:lang":"sl","#text":"tkivna rezina trebušne slinavke miši"}],"dcterms:temporal":{"@rdf:resource":"2008-2025"},"dc:title":{"@xml:lang":"sl","#text":"Cell physiology in tissue slices| Celična fiziologija v tkivnih rezinah| preučevanje celic beta v Langerhansovih otočkih| studying beta cells in the islets of Langerhans|"},"dc:description":[{"@xml:lang":"sl","#text":"Isolated endocrine cells have enabled the development of numerous methods to assess basic cellular architecture and define a significant part of the molecular machinery involved in cellular processes, such as excitability or the exocytotic release of hormones following cytosolic calcium increase. These efforts have generated consensus models explaining the activation or general operation of a particular cell type. The use of fresh tissue slices can go even further and uncover a series of emergent properties never explained or predicted by consensus models. In this paper, we present a selection of our most important experimental findings in the beta cells of pancreatic tissue slices"},{"@xml:lang":"sl","#text":"Uporaba izoliranih endokrinih celic je omogočila razvoj številnih metod za oceno osnovne celične arhitekture in opredelitev pomembnega dela molekularnih mehanizmov, ki sodelujejo pri celičnih procesih, kot sta vzdražnost celic in izločanje hormonov v procesu eksocitoze po porastu znotrajcelične koncentracije kalcijevih ionov. Ta prizadevanja so vodila v oblikovanje dogovornih modelov, ki razlagajo aktivacijo in splošen način delovanja določenega celičnega tipa. Z uporabo svežih tkivnih rezin lahko presežemo dosedanje raziskave in razkrijemo celo vrsto porajajočih se lastnosti, ki jih dogovorni modeli ne morejo zlahka predvideti niti razložiti. V tem članku predstavljamo izbor naših najpomembnejših eksperimentalnih ugotovitev na celicah beta v tkivnih rezinah trebušne slinavke"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-JEN8WMND","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-JEN8WMND"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-JEN8WMND/03e0fbab-8b63-42d4-ba34-78dd4b639333/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Univerza v Mariboru, Medicinska fakulteta"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-JEN8WMND/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-JEN8WMND"}}}}