44 KB238 KB41 KB200520252012Kocbek, Petraštevilka:2letnik:63str. 75-81ISSN:0014-8229COBISSID:3243633URN:URN:NBN:SI:doc-JB9BG0WRslSlovensko farmacevtsko društvoFarmacevtski vestnikdostavni sistemidrugnanoantibiotikinanotehnologijananoteranostikinanovlaknazdravilaNovosti na področju farmacevtske nanotehnologije| Novelties in the field of pharmaceutical nanotechnology|Pharmaceutical nanotechnology has been under intensive development for more than four decades and shows a significant impact on the diagnosis and treatment of many diseases. Its main goal is development of modern nanodelivery systems for more effective therapy and reduced occurrence of side effects. The results of the current development are ŽsmartŽ bioresponsive nanodelivery systems, nanosystems for active targeting and nanosystems for targeting on subcellular level. Novel nanodelivery systems can overcome barriers in the body and enable the drug delivery to the locations which are out of reach for classical formulations (e.g. brain delivery). New formulation methods have also emerged. The main focus being on self-assembly technologies, which enable incorporation of modern macromolecular drugs (peptides, proteins, genes). All these and many other innovations in the field of pharmaceutical nanotechnology promise better monitoring and therapy of nowadays incurable or poorly treatable diseases, resulting in improved patient's quality of lifeFarmacevtska nanotehnologija se intenzivno razvija že dobra štiri desetletja in ima pomemben vpliv na odkrivanje in zdravljenje številnih bolezni. Njen cilj je razviti sodobne nanodostavne sisteme, ki bodo povečali učinkovitost zdravljenja in zmanjšali pojav stranskih učinkov. Tako so rezultat razvoja >>pametni<< bioodzivni nanodostavni sistemi, nanosistemi za aktivno ciljanje in nanosistemi za ciljanje na subceličnem nivoju. Novi nanodostavni sistemi omogočajo premagovanje barier v organizmu in vnos učinkovin na mesta, ki so s klasičnimi farmacevtskimi oblikami nedostopna (npr. vnos v možgane). Novosti so tudi na področju metod za izdelavo nanosistemov, kjer so v ospredju metode,ki temeljijo na samozdruževanju gradnikov in omogočajo vgrajevanje sodobnih makromolekularnih učinkovin (peptidi, proteini, geni). Vse omenjene in še številne druge novosti na področju farmacevtske nanotehnologije obetajo boljše spremljanje in zdravljenje danes neozdravljivih ali težko ozdravljivih bolezni ob sočasno izboljšani kakovosti bolnikovega življenjaTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo