972 KB36 KB200520252019Gramec, DarjaPeterlin-Mašič, Lucijaštevilka:3letnik:70str. 196-204ISSN:0014-8229COBISSID_HOST:4765041URN:URN:NBN:SI:doc-J4QM97T5slSlovensko farmacevtsko društvoFarmacevtski vestnikandrogeni receptorendokrini sistemestrogenski receptormotilci endokrinega sistemaučinkovineKemični motilci endokrinega sistema| Endocrine disrupting chemicals|Various compounds of both natural and synthetic origin can interfere with endocrine system and consequently adversely affect human health. Exposure to endocrine disruptors is associated with numerous common diseases, such as obesity, diabetes, cardiovascular diseases, infertility in women and men, and cancer. Endocrine disruptors can exert their effects through different mechanisms: (i) they interfere with synthesis, metabolism, transport or elimination of endogenous hormones; (ii) they are agonists or antagonists of selected endocrine receptors, or (iii) bind to membrane receptors and cause nongenomic effects. In this review article, influences of endocrine disruptors, predominantly active substances, on estrogen, androgen, thyroid and glucocorticoid systems will be presented together with their impact on human healthZa številne spojine tako naravnega kot sinteznega izvora je znano, da motijo delovanje endokrinega sistema in imajo posledično škodljiv vpliv na zdravje posameznika. Izpostavljenost motilcem endokrinega sistema je povezana s številnimi boleznimi sodobnega časa, kot so debelost, sladkorna bolezen, srčno-žilne bolezni, neplodnost pri ženskah in moških ter rakave bolezni. motilci endokrinega sistema delujejo po različnih mehanizmih: (i) motijo sintezo, metabolizem, transport ali izločanje endogenih hormonov, (ii) vežejo se na izbrane endokrine receptorje, na katerih so agonisti ali antagonisti, ali (iii) vežejo se na membranske receptorje in povzročijo negenomske učinke. V tem preglednem članku bomo predstavili delovanje motilcev endokrinega sistema, zlasti učinkovin, v estrogenskem, androgenem, tiroidnem in glukokortikoidnem sistemu ter njihov vpliv na zdravje človekaTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo