122 KB35 KB199420252024Kokalj Palandačić, AnjaRus Prelog, PolonaTavčar, Rokštevilka:4letnik:63str. 367-376ISSN:0025-8121COBISSID:224127235URN:URN:NBN:SI:doc-J2O99O1TslMedicinski razglediMedicinski razglediantipsihotikikompulzijaobsesijaobsesivno-kompulzivna motnjashizofrenijaObsesivno-kompulzivni simptomi pri bolnikih s shizofrenijo| Obsessive-compulsive symptoms in patients with schizophrenia|Obsessions and compulsions are characteristic of obsessive-compulsive disorder, but similar phenomena also occur in patients with psychosis in the schizophrenic spectrum of psychotic disorders. Approximately one third of patients with schizophrenia suffer from obsessive-compulsive symptoms, which are often clinically overlooked or mistaken for positive symptoms. Three groups of obsessive-compulsive symptoms are associated with schizophrenia: obsessive-compulsive symptoms in the prodrome of schizophrenia, co-occurrence of obsessive-compulsive disorder and schizophrenia, and obsessive-compulsive symptoms induced by antipsychotics. The presence of obsessive-compulsive symptoms is 1 Dr. associated with a worse prognosis and negative outcomes of schizophrenia treatment. Proper treatment requires a detailed assessment of symptoms. In the case of obsessive- -compulsive symptoms caused by the use of antipsychotics, it is necessary to reduce or change the antipsychotic or, in extreme cases, add an antidepressant from the group of selective serotonin reuptake inhibitors. In this review article, we present the clinical features of obsessive-compulsive symptoms in patients with schizophrenia, obsessive-compulsive symptoms induced by antipsychotics, and their treatmentObsesije in kompulzije so značilne za obsesivno-kompulzivno motnjo, a se pojavljajo tudi pri bolnikih s psihozo v shizofrenskem spektru psihotičnih motenj. Približno ena tretjina bolnikov s shizofrenijo trpi zaradi obsesivno-kompulzivnih simptomov, ki so pogosto klinično spregledani ali pa jih zamenjamo za pozitivne simptome. Ločimo tri skupine obsesivno-kompulzivnih simptomov, ki so povezani s shizofrenijo: obsesivno-kompulzivni simptomi v prodromu shizofrenije, sočasno pojavljanje obsesivno-kompulzivne motnje in shizofrenije ter z antipsihotiki povzročeni obsesivno-kompulzivni simptomi. Prisotnost obsesivno-kompulzivnih simptomov je povezana s slabšo prognozo in negativnimi izidi zdravljenja shizofrenije. Njihova obravnava zahteva pravilno oceno nastanka simptomov, šele nato lahko načrtujemo zdravljenje. Pri obsesivno-kompulzivnih simptomih, nastalih zaradi uporabe antipsihotikov, je treba odmerek antipsihotika znižati, ga zamenjati in/ali v skrajnem primeru dodati antidepresiv iz skupine selektivnih zaviralcev ponovnega privzema serotonina. V preglednem članku bomo prikazali klinične značilnosti obsesivno- kompulzivnih simptomov pri bolnikih s shizofrenijo, povezanost teh simptomov z antipsihotiki in njihovo obravnavoTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi