{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ITV5ASQW/33f79e00-3b49-4d91-9660-0d18d08a7919/HTML","dcterms:extent":"81 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ITV5ASQW/347ddf21-9c4e-43cf-8cdc-8c6347f54ed5/PDF","dcterms:extent":"401 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ITV5ASQW/a8a51f51-3ca5-4d76-a1f2-c6ac991b7d71/TEXT","dcterms:extent":"69 KB"}],"edm:TimeSpan":{"@rdf:about":"1998-2025","edm:begin":{"@xml:lang":"en","#text":"1998"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-ITV5ASQW","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-KC6O72BG"},{"@xml:lang":"sl","#text":"Acta chimica slovenica"}],"dcterms:issued":"2011","dc:creator":["Blanot, Didier","Frlan, Rok","Gobec, Stanislav","Kovač, Andreja","Obreza, Aleš","Pečar, Slavko"],"dc:format":[{"@xml:lang":"sl","#text":"številka:2"},{"@xml:lang":"sl","#text":"letnik:58"},{"@xml:lang":"sl","#text":"str. 295-310"}],"dc:identifier":["ISSN:1318-0207","COBISSID:3047281","URN:URN:NBN:SI:doc-ITV5ASQW"],"dc:language":"en","dc:publisher":[{"@xml:lang":"sl","#text":"Slovenian Chemical Society"},{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"}],"dc:subject":[{"@xml:lang":"sl","#text":"biosinteza"},{"@xml:lang":"en","#text":"ligaze"},{"@xml:lang":"sl","#text":"peptidoglikan"}],"dcterms:temporal":{"@rdf:resource":"1998-2025"},"dc:title":{"@xml:lang":"sl","#text":"Design, synthesis and in vitro biochemical activity of novel amino acid sulfonohydrazide inhibitors of murC|"},"dc:description":[{"@xml:lang":"sl","#text":"Mur ligases are essential enzymes involved in the cytoplasmic steps of peptidoglycan synthesis which remain attractive, yet unexploited targets. In order to develop new antibacterial agents, we have designed a series of new MurC and Mur- D inhibitors bearing amino acid sulfonohydrazide moiety. The L-Leu series of this class displayed the highest enzyme inhibition with IC50 in the concentration range between 100 and 500 iM, with L-Thr, L-Pro and L-Aladerivatives being inactive. The most promising compound of the series also expressed weak antibacterial activity against S. aureus with MIC = 128 microg/mL"},{"@xml:lang":"sl","#text":"Ligaze Mur so esencialni encimi za bakterije, ki sodelujejo v citoplazemskih stopnjah biosinteze peptidoglikana. Predstavljajo zanimive, vendar še ne dovolj izkoriščene tarče za protimikrobne učinkovine. Z namenom priprave novih protibakterijskih učinkovin, smo načrtovali in sintetizirali serijo novih zaviralcev MurC in MurD, ki vsebujejo aminokislinski sulfonohidrazidni fragment. Predstavniki z L-Leu so najbolj zavirali oba encima in so imeli IC50vrednosti v koncentracijskem območju 100-500 microM. Derivati z L-Thr, L- Pro in L-Ala so bili praktično neaktivni. Najobetavnejša učinkovina je imela izraženo tudi šibko protibakterijsko delovanje na S. aureus z MIC = 128 microg/L"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-ITV5ASQW","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-ITV5ASQW"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-ITV5ASQW/347ddf21-9c4e-43cf-8cdc-8c6347f54ed5/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-ITV5ASQW/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-ITV5ASQW"}}}}