32 KB145 KB31 KB200520252007Mlinarič-Raščan, IrenaŠtrukelj, BorutŽiberna, KlemenŽiberna, Lovroštevilka:4letnik:586 stranistr. 139-144ISSN:0014-8229COBISSID:2230897URN:URN:NBN:SI:doc-IQD3FYIYslSlovensko farmacevtsko društvoFarmacevtski vestnikdetekcija dopingaeritropoetingenski dopingmiostatinMožnosti uporabe genskega dopinga in problemi njegove detekcije|Gene doping is defined as the non-therapeutic use of cells, genes, genetic elements, or of the modulation of gene expression, having the capacity to enhance athletic performance. The purpose of gene insertion into the target cells is to improve physiological abilities by vast production of protein thatamplifies or inhibits certain signalling pathways. Insertion of genes for erythropoietin, IGF-1, myostatin inhibitors, VEGF and PPAR-delta in animals has shown major rise in aerobic capabilities, prolonged endurance and increased muscle strength. However, several problems with efficiency and specificity of gene transfer exist and call attention to safety and health concerns. Also, no adequate non-invasive and sensitive detection method exists for gene dopingGenski doping je neterapevtska uporaba celic, genov, genskih elementov ali modulacija genske ekspresije, katere cilj je izboljsati sposobnosti sportnika.Namen vnosa genskega materiala v celice tarenih tkiv je poveeana ekspresija proteinov, ki regulirajo signalne poti in povzroeijo izboljsanje zelenih fizioloskih parametrov. Vnosi genskih zapisov za eritropoetin, IGF-1, inhibitorje miostatina, VEGF in PPAR-delta v celice tarenih tkiv zivali izboljsajo aerobne sposobnosti, podaljsajo vzdrzljivost in zveeajo misieno moe. Tezave z ueinkovitostjo in specifienostjo prenosa genskega materiala v telo predstavljajo tveganje za organizem. Zaenkrat se ne poznamo primernega testa za detekcijo genskega dopinga, ki bi imel ustrezno obeutljivost in specifienost ter bi bil hkrati neinvazivenTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo