{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-IL121FKA/696a4233-75ae-4f80-9dda-9b8adbf17121/PDF","dcterms:extent":"455 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-IL121FKA/dc66ef1d-a471-4e9d-a958-309fee8cecc9/TEXT","dcterms:extent":"0 KB"}],"edm:TimeSpan":{"@rdf:about":"2005-2025","edm:begin":{"@xml:lang":"en","#text":"2005"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-IL121FKA","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-8ER5ZBJN"},{"@xml:lang":"sl","#text":"Farmacevtski vestnik"}],"dcterms:issued":"2024","dc:creator":"Baumgartner, Ana","dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:75"},{"@xml:lang":"sl","#text":"str. 34-42"}],"dc:identifier":["ISSN:0014-8229","COBISSID_HOST:192524035","URN:URN:NBN:SI:doc-IL121FKA"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"bolnikom prijazne farmacevtske oblike"},{"@xml:lang":"en","#text":"coprocessed excipients"},{"@xml:lang":"en","#text":"direct compression"},{"@xml:lang":"sl","#text":"direktno stiskanje"},{"@xml:lang":"sl","#text":"Etika"},{"@xml:lang":"sl","#text":"Farmacevtske oblike"},{"@xml:lang":"sl","#text":"koprocesirane pomožne snovi"},{"@xml:lang":"en","#text":"orodispersible tablets"},{"@xml:lang":"sl","#text":"orodisperzibilne tablete"},{"@xml:lang":"en","#text":"patient-friendly dosage forms"},{"@xml:lang":"sl","#text":"Tablete"}],"dcterms:temporal":{"@rdf:resource":"2005-2025"},"dc:title":{"@xml:lang":"sl","#text":"Uporaba koprocesiranih pomonih snovi pri izdelavi orodisperznibilnih tablet| Use of coprocessed excipients in orodispersible tablets|"},"dc:description":[{"@xml:lang":"sl","#text":"In the last years, there is a growing tendency for development of patient-friendly dosage forms. Among these, orodispersible tablets show great potential, as they disintegrate in the oral cavity before patients swallow them, which can improve patient compliance. The simplest and economically favourable approach for their production is direct compression. However, this requires the powder blend to have adequate properties, which can be achieved by implementing coprocessed excipients. These are a mixture of more excipients, in which physical properties of separate components are altered in a way that is not achievable by simple physical blending, and without any significant chemical changes. There are already a few coprocessed excipients on the market, intended for production of orodispersible tablets by direct compression. Nevertheless, it has to be acknowledged that the price of coprocessed excipients is still higher than for one-component excipients and that their registration is more complicated from a regulatory perspective"},{"@xml:lang":"sl","#text":"V zadnjih letih dajemo v farmacevtskem razvoju vse več poudarka na razvoj bolnikom prijaznih farmacevtskih oblik. Mednje spadajo tudi orodisperzibilne tablete, ki v ustih razpadejo, še preden jih bolniki pogoltnejo. S tem lahko ključno prispevamo k sodelovanju bolnikov pri zdravljenju. Najbolj enostaven in stroškovno ugoden način izdelave orodisperzibilnih tablet je direktno stiskanje, za kar pa potrebujemo zmes prahov za tabletiranje z ustreznimi lastnostmi. Pri tem nam lahko pomaga uporaba koprocesiranih pomožnih snovi. V njih je združenih več posameznih pomožnih snovi, s čimer se njihove fizikalne lastnosti spremenijo na način, ki ga ni mogoče doseči s preprostim fizikalnim mešanjem, ter brez bistvenih kemijskih sprememb. Na trgu že obstaja več koprocesiranih pomožnih snovi, ki so posebej namenjene za izdelavo orodisperzibilnih tablet z direktnim stiskanjem. Poudariti pa je treba, da je cena koprocesiranih snovi še vedno višja kot pri enostavnih pomožnih snoveh ter da je pridobivanje dovoljenja za promet tovrstnega zdravila bolj zapleteno"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-IL121FKA","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-IL121FKA"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-IL121FKA/696a4233-75ae-4f80-9dda-9b8adbf17121/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-IL121FKA/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-IL121FKA"}}}}