112 KB39 KB199420252009Marovt, Maruškaštevilka:3letnik:48str. 257-266ISSN:0025-8121COBISSID:26024409URN:URN:NBN:SI:doc-HBAHVY8GslMedicinski razglediMedicinski razgledidermatologijaeozinofilijaHipereozinofilni sindromHypereosinophilic SyndromeKožne manifestacijeSkin ManifestationsDermatološke manifestacije hiperezinofilnega sindroma| Dermatologic manifestations of the hypereosinophilic syndrome|Hypereosinophilic syndrome represents a range of rare and heterogeneous disorders sharing three features: peripheral eosinophil count higher than 1.5 x 109/L for over 6 months, evidence of organ involvement and absence of other causes of eosinophilia, such as allergy, parasite infestation and malignancy. Hypereosinophilic syndrome may present with various cutaneous abnormalities. Over 50% of such patients have pruritic erythematous macules, papules, plaques, wheals, nodules, or other skin lesions during the course of the disease. The diagnosis of hypereosinophilic syndrome may be delayed or missed because the association between cutaneous lesions and hypereosinophilic syndrome is not appreciated. The presence of eosinophils in normal tissues is surprisingly selective. Eosinophil infiltration or degranulation is not se en in skin samples from normal persons. The treatment goal for patients with hypereosinophilic syndrome is to provide relief of symptoms and improvement inorgan function while keeping eosinophils in peripheral blood at 1000-ZOOO/mLand minimizing side effectsTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi