39 KB1606 KB36 KB200520252005Kristan, KatjaLanišnik-Rižner, Tea10 straništevilka:3letnik:56str. 259-268ISSN:0014-8229COBISSID:20222169URN:URN:NBN:SI:doc-H318RJWTslSlovensko farmacevtsko društvoFarmacevtski vestnikandrogenibiosintezaestrogenihormoniinhibitorji17beta-hidroksisteroid-dehidrogenaze - obetajoče farmakološke tarče|The 17beta-hydroxysteroid dehydrogenases (17beta-HSDs) have important roles inthe regulation of steroid hormone actions through their catalysis of the oxidation or reduction of estrogens and androgens at position 17. To date, 11 different human 17beta-HSDs have been described Dysfunction of the human 17beta-HSDs results in reproduction disorders and neuronal diseases, and in the development of hormonedependent cancers. This review summarizes current knowledge on the medical implications of the 17beta-HSDs and presents some representative inhibitors of the different 17beta-HSD isozymesTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo