1607 KB25 KB200520252021Kocbek, Petraštevilka:4letnik:72str. 242-248ISSN:0014-8229COBISSID:77019395URN:URN:NBN:SI:doc-GSV0UW8DslSlovensko farmacevtsko društvoFarmacevtski vestnikbakterijebarierna funkcijaKožamikrobiommikrobiotaMikrobiota zdrave kože - zapostavljena zaščitna bariera| Skin microbiota - neglected protective barrier|The skin microbiota is a community of all microorganisms (bacteria, fungi, viruses, microeukaryotes, and bacteriophages) on and in the skin, whereas the set of their genomes is called the skin microbiome. It has been proven that the microbiota is an important biological barrier that, in symbiosis with the skin, protects the organism and enables the normal function of the immune system. It is important to know the factors that can positively or negatively affect the microbiota, and thus maintain its healthy state or disturb the balance in the microbial community, i.e. they cause dysbiosis. The knowledge about species composition and roles of individual microorganisms in the microbiota is also important for understanding of the skin condition and potential pathological changes that occured. Based on this knowledge the approaches to improve the skin condition or treatment of skin diseases associated with the skin barrier dysfunction can be designedMikrobiota kože je združba vseh mikroorganizmov (bakterij, gliv, virusov, mikroevkariontov in bakteriofagov), ki se nahajajo na in v koži; skupek njihovih genomov pa imenujemo mikrobiom kože. Danes je dokazano, da je mikrobiota pomembna biološka bariera, ki v simbiozi s kožo ščiti organizem in omogoča normalno delovanje imunskega sistema. Pomembno je, da poznamo dejavnike, ki lahko pozitivno ali negativno vplivajo na mikrobioto. Tako bodisi vzdržujejo njeno zdravo stanje ali pa rušijo ravnovesje v združbi mikroorganizmov in povzročajo disbiozo. Poznavanje sestave in vloge posameznih mikroorganizmov v mikrobioti pa je pomembno tudi za razumevanje stanja kože in potencialnih patoloških sprememb ter za načrtovanja pristopov za izboljšanje stanja kože ali zdravljenje bolezni, ki so povezane z motnjami v barierni funkciji kožeTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo