{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-GN7J32MC/2f-c5e-89b4251a1-ba0a4b1bd97c314c-d4/PDF","dcterms:extent":"1039 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-GN7J32MC/da23668d-6a50-4de6-8a9d-133a02f805ab/TEXT","dcterms:extent":"31 KB"}],"edm:TimeSpan":{"@rdf:about":"2022-2025","edm:begin":{"@xml:lang":"en","#text":"2022"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-GN7J32MC","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-UCB4A42Q"},{"@xml:lang":"sl","#text":"Placebo"}],"dcterms:issued":"2022","dc:creator":"Trunkelj, Natalija","dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"str. 57-62"}],"dc:identifier":["COBISSID_HOST:122934019","ISSN:2820-5014","URN:URN:NBN:SI:doc-GN7J32MC"],"dc:language":["en","sl"],"dc:publisher":{"@xml:lang":"sl","#text":"Fakulteta za farmacijo, ŠSSFD"},"dc:subject":[{"@xml:lang":"en","#text":"autoimmune diseases"},{"@xml:lang":"sl","#text":"Avtoimunske bolezni"},{"@xml:lang":"en","#text":"diet"},{"@xml:lang":"en","#text":"environment"},{"@xml:lang":"en","#text":"infections"},{"@xml:lang":"sl","#text":"Infekcije"},{"@xml:lang":"sl","#text":"Okolje"},{"@xml:lang":"sl","#text":"Prehrana"},{"@xml:lang":"sl","#text":"Stres"},{"@xml:lang":"en","#text":"stress"},{"@xml:lang":"sl","#text":"Toksini"},{"@xml:lang":"en","#text":"toxins"}],"dcterms:temporal":{"@rdf:resource":"2022-2025"},"dc:title":{"@xml:lang":"sl","#text":"Vpliv okolja na razvoj avtoimunskih bolezni|"},"dc:description":[{"@xml:lang":"sl","#text":"Autoimmune diseases are chronic diseases whose management, despite advances in treatment and diagnosis, remains unsatisfactory and are associated with significant disability and premature mortality, with significant personal, social and economic consequences. The number of patients, suffering from autoimmune diseases has been steadily increasing year by year and they represent an increasing burden on public healthcare. Thus, more resources are being funnelled into the field. From currently existing data the main factors that impact the immune tolerance negatively are internal ones (the genetic predisposition, the immune system’s shortcomings, hormones (gender, stress)), and external ones (Infections, smoking, medications, nutrition, environmental toxins, intestinal microbiota). People of the modern world are more than ever heavily exposed to detrimental environmental factors, mostly due to excessive pollution. The purpose of the article is to present individual environmental factors, what we know about their effect on the development of autoimmune diseases and the mechanisms responsible for autoimmunity. It is crucial to discover environmental factors, that trigger specific autoimmune diseases, which would allow for the development of precautionary programs to commence and could preserve the health of millions of people. The objective of this article is to encourage further research in the field"},{"@xml:lang":"sl","#text":"Avtoimunske bolezni so kronične bolezni, katerih obvladovanje je kljub napredku v zdravljenju in diagnostiki še vedno nezadovoljivo in so povezane z znatno invalidnostjo in prezgodnjo umrljivostjo ter imajo pomembne osebne, družbene in gospodarske posledice. Število obolelih z avtoimunskimi boleznimi iz leta v leto raste, zato predstavljajo vedno večje breme za javno zdravstvo, kar je razlog, da temu področju namenjamo več pozornosti. Po do sedaj znanih podatkih na imunsko toleranco negativno vplivajo notranji dejavniki (genetska predispozicija, pomanjkljivosti imunskega sistema, hormoni – spol in stres) in zunanji, okoljski dejavniki (infekcije, kajenje, zdravila, prehrana, toksini iz okolja, izpostavljenost sončni svetlobi, črevesna mikrobiota). Ljudje razvitega sveta so zaradi velikega onesnaženja z okoljskimi dejavniki veliko bolj obremenjeni kot v preteklosti, kar vpliva tudi na povečano pojavnost avtoimunskih obolenj. Namen članka je predstaviti posamezne okoljske dejavnike ter pojasniti, kaj je znanega o njihovem vplivu na razvoj avtoimunskih obolenj in kakšni so prepoznani mehanizmi, ki pripeljejo do razvoja avtoimunosti. Ključnega pomena je, da odkrijemo okoljske dejavnike, ki so sprožitelji avtoimunskih bolezni, kar je nujno za razvoj preventivnih programov, da bi ohranili zdravje milijonov ljudi. Namen prispevka je spodbuditi strokovno javnost k nadaljnjim raziskavam na tem področju"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-GN7J32MC","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-GN7J32MC"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-GN7J32MC/2f-c5e-89b4251a1-ba0a4b1bd97c314c-d4/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:dataProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-GN7J32MC/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-GN7J32MC"}}}}