{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-FRXJ2EWF/7fd8753c-2e4e-4ce6-ae99-d22ff649524c/HTML","dcterms:extent":"17 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-FRXJ2EWF/43550b41-2233-4d00-ae77-e6eab3b9fc13/PDF","dcterms:extent":"96 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-FRXJ2EWF/7fdadce1-fb6d-445e-80ff-b3971f08a906/TEXT","dcterms:extent":"14 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-FRXJ2EWF","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:SPR-WQVGMCSC"},{"@xml:lang":"sl","#text":"Acta dermatovenerologica Alpina, Pannonica et Adriatica"}],"dcterms:issued":"2006","dc:creator":["Baran, Eugeniusz","Baran, Wojciech","Mazur, Grzegorz","Szepietowski, Jacek C."],"dc:format":[{"@xml:lang":"sl","#text":"letnik:15"},{"@xml:lang":"sl","#text":"številka:3"},{"@xml:lang":"sl","#text":"str. 113-118"}],"dc:identifier":["ISSN:1318-4458","COBISSID:21825753","URN:URN:NBN:SI:doc-FRXJ2EWF"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovene Welding Society"},"dc:subject":[{"@xml:lang":"sl","#text":"Aleli"},{"@xml:lang":"en","#text":"Alleles"},{"@xml:lang":"en","#text":"Genetics"},{"@xml:lang":"sl","#text":"genetika"},{"@xml:lang":"sl","#text":"Genotip"},{"@xml:lang":"en","#text":"Genotype"},{"@xml:lang":"sl","#text":"kožne bolezni"},{"@xml:lang":"sl","#text":"Polimerazna, verižna reakcija"},{"@xml:lang":"sl","#text":"Polimorfizem (genetika)"},{"@xml:lang":"en","#text":"Polymerase Chain Reaction"},{"@xml:lang":"en","#text":"Polymorphism (Genetics)"},{"@xml:lang":"en","#text":"Promoter Regions (Genetics)"},{"@xml:lang":"sl","#text":"Promoterska področja (genetika)"},{"@xml:lang":"en","#text":"Psoriasis"},{"@xml:lang":"sl","#text":"Psoriaza"},{"@xml:lang":"en","#text":"Tumor Necrosis Factor"},{"@xml:lang":"sl","#text":"Tumor nekrotizirajoči faktor"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"A -308 promoter polymorphism of tumor necrosis factor alpha gene does not associate with the susceptibility to psoriasis vulgaris. No difference either between psoriasis type I and type II patients|"},"dc:description":{"@xml:lang":"sl","#text":"Background: Genes encoded within the MHC complex on chromosome 6 are thought to play an important role in the pathogenesis of psoriasis. A potential candidate is tumor necrosis factor alpha (TNF-alpha) gene. Psoriasis features an increased activity of the proinflammatory cytokine TNF-alpha in affected lesions. TNF-alpha promoter region contains several polymorphisms, including GžA transition at position -308, which influences transcriptional activity of TNF-alpha. This study was performed to investigate the association between TNF-alpha single nucleotide polymorphism and susceptibility for psoriasis vulgaris. Material and methods: DNA from 78 patients with psoriasis vulgaris and 74 healthy volunteers with no personal and family history of psoriasis wasinvestigated. TNF-alpha promoter gene single nucleotide polymorphism (SNP) in position - 308 was evaluated by PCR-SSP The results were compared between group of psoriatic patients, divided into early onset of psoriasis (type I) and late onset of psoriasis (type II) subgroups, and healthy subjects. Results: There were no significant differences in the polymorphism of TNF-alpha promoter -308 (genotype distribution, allele frequencies) between psoriasis patients and healthy controls. Similar results were obtained analyzing subgroups of psoriasis patients (type I and type II of psoriasis) and gender groups. Conclusion: TNF-alfa promoter single nucleotide polymorphism (-308) is not associated with susceptiy bility to psoriasis vulgaris"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-FRXJ2EWF","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-FRXJ2EWF"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-FRXJ2EWF/43550b41-2233-4d00-ae77-e6eab3b9fc13/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Združenje slovenskih dermatovenerologov"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-FRXJ2EWF/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-FRXJ2EWF"}}}}