130 KB28 KB199420252010Orel, Rokštevilka:4letnik:49str. 479-485ISSN:0025-8121COBISSID:28092889URN:URN:NBN:SI:doc-FBQDYVWYslMedicinski razglediMedicinski razglediColonic Diseases, Functionalčrevesjedebelo črevoDebelo črevo, bolezni funkcionalneDiagnosisdiagnostikafunkcionalne motnjemotnjepatofiziologijaPhysiopathologyTherapyzdravljenjeSindrom razdražljivega črevesja| Irritable bowel syndrome|Irritable bowel syndrome (lES) is a functional bowel disorder characterized byabdominal pain or discomfort with altered frequency of defecation and stool consistency. Some people with lES also experience urgency for bowel movements,feeling of incomplete sto ol evacuation, straining and cramping during defecation, presence of mucus in sto ol, abdominal disten ti on and flatulence. lES is believed to be the consequence of several factors: altered bowel motility and sensitivity (visceral hypersensitivity), altered brain-gut axis function, low-grade mucosal inflammation, disturbed balance of intestinalmicrobiota, chemical irritation, action of psychogenic factors and (at least in some case s) genetic predisposition. When there are no alarm signs, the diagnosis of lES can be made on the basis of clinical presentation alone. When alarm signs, such as rectal bleeding, fever, high erythrocyte sedimentation rate, weight loss, failure to thrive (children) or positive family history for organic bowel disease (chronic inflammatory bowel disease, cancer) are present, accurate diagnostics is necessary. When treating patiems with IBS, education and a trustful patient-doctor relationship are necessary, with emphasis on IBS being a benign disorder that only rarely leads to seriousconsequences.Some patients benefit from excluding nutrients that are known to cause discomfort from their dieto However, most patients do not need a specific dieto Special probiotics having effects validated by high-quality clinical trials may be useful in treating patients with IBS. When memal factors play an important part, psycho therapy mayaIso have a role. The use ofmedications, however, is reserved only for resistant forms of IBSTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi