{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-EEOJT1Z6/1c22a13f-9852-4554-bb03-18b795c0e794/PDF","dcterms:extent":"188 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-EEOJT1Z6/8cd2a21f-8042-466d-8201-fde4aceedd3e/TEXT","dcterms:extent":"24 KB"}],"edm:TimeSpan":{"@rdf:about":"2022-2025","edm:begin":{"@xml:lang":"en","#text":"2022"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-EEOJT1Z6","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-UCB4A42Q"},{"@xml:lang":"sl","#text":"Placebo"}],"dcterms:issued":"2024","dc:creator":["Bizjak, Ela","Karakaš, Izidora"],"dc:format":[{"@xml:lang":"sl","#text":"številka:3"},{"@xml:lang":"sl","#text":"str. 17-20"}],"dc:identifier":["COBISSID_HOST:208869123","ISSN:2820-5014","URN:URN:NBN:SI:doc-EEOJT1Z6"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Fakulteta za farmacijo, ŠSSFD"},"dc:subject":[{"@xml:lang":"sl","#text":"Alzheimerjeva bolezen"},{"@xml:lang":"sl","#text":"antioksidanti"},{"@xml:lang":"sl","#text":"Nevrodegenerativne bolezni"},{"@xml:lang":"sl","#text":"Oksidativni stres"},{"@xml:lang":"sl","#text":"Parkinsonova bolezen"},{"@xml:lang":"sl","#text":"reaktivne kisikove zvrsti"}],"dcterms:temporal":{"@rdf:resource":"2022-2025"},"dc:title":{"@xml:lang":"sl","#text":"Vpliv oksidativnega stresa na razvoj nevrodegenerativnih bolezni|"},"dc:description":[{"@xml:lang":"sl","#text":"Physiologically, oxygen plays a dual role. On one hand, it is a vital molecule for respiration and cell survival, while also having the capability to form multiple reactive species. These reactive species serve important functions when present in controlled concentrations. However, when they are formed in excess, they can cause biochemical damage to cell membranes, nucleic acids, proteins, and other biomolecules. This underscores the critical need for robust antioxidant support for the survival of aerobic organisms. The brain is highly metabolically active, with significant oxygen consumption and relatively low antioxidant capacity, making it particularly susceptible to oxidative stress. This oxidative stress may contribute to specific neuronal death patterns characteristic of neurodegenerative diseases, although direct causation has not been definitively established. In diseases like Alzheimer's and Parkinson's, protein adducts of key enzymes can develop as a result of oxidative stress. To better assess oxidative stress, improved analytical methods are needed. However, the use of antioxidants in the treatment of neurodegenerative diseases has not yet demonstrated clear beneficial effects"},{"@xml:lang":"sl","#text":"Kisik ima v telesu dvojno vlogo. Po eni strani omogoča celično dihanje in preživetje celice, po drugi strani pa tvori številne reaktivne zvrsti. Kadar so reaktivne zvrsti v omejenih koncentracijah, prevladujejo njihovi fiziološki učinki. Pretirana tvorba reaktivnih molekul povzroča biokemične poškodbe membran, nukleinskih kislin, proteinov in drugih bioloških molekul. Razvoj antioksidativne mreže, ki ohranja ravnovesje med redukcijami in oksidacijami, je bil zato ključen za preživetje aerobov. Možgani so metabolno zelo obremenjeni, porabljajo veliko kisika in imajo šibko antioksidantno zaščito, zato so še posebej dovzetni za oksidativne poškodbe, ki jih povzročajo reaktivne zvrsti. Obstaja možnost, da to povzroča specifično odmiranje nevronov, kar vodi v razvoj nevrodegenerativnih bolezni. Dokazov o vzročno-posledični korelaciji nimamo. Za Alzheimerjevo in Parkinsonovo bolezen so značilni poškodbe določenih encimov in nastanek proteinskih aduktov, ki jih lahko pripišemo oksidativnemu stresu. Za boljše vrednotenje vpliva oksidativnega stresa je treba razviti zanesljivejše in natančnejše metode vrednotenja. Zdravljenje nevrodegenerativnih bolezni, ki oksidativni stres zmanjšuje z aplikacijo antioksidantov, pri ljudeh še ni pokazalo izboljšanja bolezni"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-EEOJT1Z6","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-EEOJT1Z6"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-EEOJT1Z6/1c22a13f-9852-4554-bb03-18b795c0e794/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:dataProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-EEOJT1Z6/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-EEOJT1Z6"}}}}