149 KB19 KB200520252014Brvar, Miranštevilka:1letnik:65str. 18-23ISSN:0014-8229COBISSID:31330521URN:URN:NBN:SI:doc-DFJL4CL6slSlovensko farmacevtsko društvoFarmacevtski vestnikbenzodiazepinebenzodiazepinioverdosepoisoningpredoziranjazastrupitveKlinično pomembne razlike, prepoznava in ukrepi pri predoziranju benzodiazepinov| Clinical features, diagnosis and treatment of benzodiapine overdose|Benzodiazepines are the most common group of drugs used in deliberate self-poisoning in Slovenia. The most frequently benzodiazepine poisoning include alprazolam, diazepam, bromazepam, lorazepam and flurazepam. Patients with a mild benzodiazepine overdose display drowsiness, dysarthria and ataxia. In large doses, benzodiazepine can cause coma and respiratory depression, and death. Flumazenil, which is a competitive antagonist of GABA receptors, can help to confirm a suspected diagnosis of benzodiazepine overdose in unconsciousness poisoned patients. The management of acute benzodiazepine poisoning is mainly supportive. In addition, flumazenil and activated charcoal could be usedTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo