{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-D3F5O8IC/42bbaf63-53af-458b-ba42-fb787632289c/PDF","dcterms:extent":"21423 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-D3F5O8IC/3e627f6d-814b-4255-ba15-9418b926e91b/TEXT","dcterms:extent":"0 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-D3F5O8IC","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:SPR-WQVGMCSC"},{"@xml:lang":"sl","#text":"Acta dermatovenerologica Alpina, Pannonica et Adriatica"}],"dcterms:issued":"2025","dc:creator":["Bukhari, Agussalim","Christopher, Paulus Mario","Djawad, Khairuddin","Irawan Anwar, Anis","Kapantow, Marlyn Grace","Mawu, Ferra Olivia"],"dc:contributor":"Mawu, Ferra Olivia","dc:format":[{"@xml:lang":"sl","#text":"letnik:34"},{"@xml:lang":"sl","#text":"številka:iss. 3"},{"@xml:lang":"sl","#text":"str. 95-99"}],"dc:identifier":["DOI:10.15570/actaapa.2025.23","ISSN:1318-4458","COBISSID_HOST:260313347","URN:URN:NBN:SI:doc-D3F5O8IC"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovene Welding Society"},"dc:subject":[{"@xml:lang":"en","#text":"acne vulgaris"},{"@xml:lang":"sl","#text":"akne vulgaris"},{"@xml:lang":"sl","#text":"dušikov oksid"},{"@xml:lang":"en","#text":"glutathione"},{"@xml:lang":"sl","#text":"glutation"},{"@xml:lang":"en","#text":"interleukin-1?"},{"@xml:lang":"sl","#text":"interlevkin-1?"},{"@xml:lang":"en","#text":"nitric oxide"},{"@xml:lang":"sl","#text":"oksidativni stres"},{"@xml:lang":"en","#text":"oxidative stress"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"Effectiveness of oral glutathione in reducing nitric oxide and IL-1? concentrations for clinical improvement in mild to moderate acne vulgaris:| a randomized controlled trial|"},"dc:description":{"@xml:lang":"sl","#text":"Introduction: Acne vulgaris (AV) is a chronic inflammatory dermatosis predominantly affecting adolescents and young adults. Oxidative and nitrosative stress, marked by elevated nitric oxide (NO) and interleukin (IL)-1?, contributes to AV pathogenesis. Glutathione, a key antioxidant, may attenuate oxidative and nitrosative stress and modulate inflammatory pathways. This study investigates the effectiveness of oral glutathione supplementation on serum NO and IL-1? concentrations, and clinical improvement in mild to moderate AV patients. Methods: A randomized controlled trial was conducted involving 40 subjects diagnosed with mild to moderate AV. Participants were randomized to receive either 500 mg oral glutathione (n = 22) or placebo (n = 18) once daily for 4 weeks. Clinical severity of AV was assessed utilizing the Lehmann criteria. Serum levels of NO and IL-1? were measured at baseline and week 4. Results: At week 4, reductions in serum NO and IL-1? concentrations were observed in the glutathione group; however, these changes did not reach statistical significance (p > 0.05). Clinical improvement occurred in seven subjects (31.8%) in the glutathione group, with a reduction from moderate to mild severity. No adverse reactions were reported. Conclusions: Oral glutathione supplementation demonstrated a non-significant trend toward reducing oxidative and nitrosative stress markers and improving mild to moderate AV. Further studies are recommended to validate these findings"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-D3F5O8IC","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-D3F5O8IC"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-D3F5O8IC/42bbaf63-53af-458b-ba42-fb787632289c/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Združenje slovenskih dermatovenerologov"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-D3F5O8IC/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-D3F5O8IC"}}}}