21423 KB0 KB199220252025Bukhari, AgussalimChristopher, Paulus MarioDjawad, KhairuddinIrawan Anwar, AnisKapantow, Marlyn GraceMawu, Ferra OliviaMawu, Ferra Olivialetnik:34številka:iss. 3str. 95-99DOI:10.15570/actaapa.2025.23ISSN:1318-4458COBISSID_HOST:260313347URN:URN:NBN:SI:doc-D3F5O8ICenSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et Adriaticaacne vulgarisakne vulgarisdušikov oksidglutathioneglutationinterleukin-1?interlevkin-1?nitric oxideoksidativni stresoxidative stressEffectiveness of oral glutathione in reducing nitric oxide and IL-1? concentrations for clinical improvement in mild to moderate acne vulgaris:| a randomized controlled trial|Introduction: Acne vulgaris (AV) is a chronic inflammatory dermatosis predominantly affecting adolescents and young adults. Oxidative and nitrosative stress, marked by elevated nitric oxide (NO) and interleukin (IL)-1?, contributes to AV pathogenesis. Glutathione, a key antioxidant, may attenuate oxidative and nitrosative stress and modulate inflammatory pathways. This study investigates the effectiveness of oral glutathione supplementation on serum NO and IL-1? concentrations, and clinical improvement in mild to moderate AV patients. Methods: A randomized controlled trial was conducted involving 40 subjects diagnosed with mild to moderate AV. Participants were randomized to receive either 500 mg oral glutathione (n = 22) or placebo (n = 18) once daily for 4 weeks. Clinical severity of AV was assessed utilizing the Lehmann criteria. Serum levels of NO and IL-1? were measured at baseline and week 4. Results: At week 4, reductions in serum NO and IL-1? concentrations were observed in the glutathione group; however, these changes did not reach statistical significance (p > 0.05). Clinical improvement occurred in seven subjects (31.8%) in the glutathione group, with a reduction from moderate to mild severity. No adverse reactions were reported. Conclusions: Oral glutathione supplementation demonstrated a non-significant trend toward reducing oxidative and nitrosative stress markers and improving mild to moderate AV. Further studies are recommended to validate these findingsTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov