{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-CFCNP9VF/859ca134-278e-4b1c-9e97-7a82d78fcfbb/PDF","dcterms:extent":"399 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-CFCNP9VF/e6b08d27-68bf-4ab9-ae1c-4594effec388/TEXT","dcterms:extent":"26 KB"}],"edm:TimeSpan":{"@rdf:about":"2008-2025","edm:begin":{"@xml:lang":"en","#text":"2008"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-CFCNP9VF","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-YR600LYC"},{"@xml:lang":"sl","#text":"Acta medico-biotechnica"}],"dcterms:issued":"2013","dc:creator":["Ferk, Polonca","Geršak, Ksenija","Jerenec, Katja","Samojlenko, Maša"],"dc:format":[{"@xml:lang":"sl","#text":"številka:2"},{"@xml:lang":"sl","#text":"letnik:6"},{"@xml:lang":"sl","#text":"str. 13-20"}],"dc:identifier":["COBISSID:1165228","ISSN:1855-5640","URN:URN:NBN:SI:doc-CFCNP9VF"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Medicinska fakulteta"},"dc:subject":[{"@xml:lang":"sl","#text":"farmakogenetika"},{"@xml:lang":"sl","#text":"metformin"},{"@xml:lang":"sl","#text":"sindrom policističnih jajčnikov"},{"@xml:lang":"en","#text":"therapy"},{"@xml:lang":"sl","#text":"zdravljenje"}],"dcterms:temporal":{"@rdf:resource":"2008-2025"},"dc:title":{"@xml:lang":"sl","#text":"Učinkovitost zdravljenja sindroma policističnih jajčnikov z metforminom| Efficacy of metformin treatment in polycysticovary syndrome|"},"dc:description":[{"@xml:lang":"sl","#text":"Metformin is an oral antidiabetic drug with potentially beneficial effects in patients with polycystic ovary syndrome (PCOS). Different pharmacological responses to metformin have been reported in PCOS patients, which may be attribut able to various clinical, biochemical, genetic and other factors. Here, we have outlined a short review of the results from current clinical studies on metformin efficacy in PCOS patients. Additionally, preliminary results from a retrospective pharmacogenetic study by our group on a sample of Slovene PCOS patients are presented. Pharmacogenetics is an emerging science that should provide options for individualized medicine, the future of healthcare"},{"@xml:lang":"sl","#text":"Metformin je peroralni antidiabetik, potencialno učinkovit tudi v terapiji bolnic s sindromom policističnih jajčnikov (PCOS). Med bolnicami s PCOS prihaja do opaznih razlik v farmakološkem odzivu na metformin, kar je verjetno posledica kliničnih, biokemijskih, genetskih in drugih dejavnikov. V prispevku navajamo kratek pregled ugotovitev dosedanjih kliničnih študij učinkovitosti zdravljenja bolnic s PCOS z metforminom ter hkrati povzemamo preliminarne rezultate retrospektivne farmakogenetske študije na vzorcu slovenskih bolnic s PCOS. Sodobno znanje farmakogenetike si počasi, a vztrajno utira pot v klinično prakso ter postaja pomemben segment obravnave bolnikov in eden od temeljev osebne medicine medicine prihodnosti"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-CFCNP9VF","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-CFCNP9VF"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-CFCNP9VF/859ca134-278e-4b1c-9e97-7a82d78fcfbb/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Univerza v Mariboru, Medicinska fakulteta"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-CFCNP9VF/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-CFCNP9VF"}}}}