{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-C2OBTAUQ/cec33b4f-cdaa-40ab-9817-7f0ef2726a36/PDF","dcterms:extent":"189 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-C2OBTAUQ/c17460e2-c11d-4082-8863-2fac9774095d/TEXT","dcterms:extent":"69 KB"}],"edm:TimeSpan":{"@rdf:about":"1994-2025","edm:begin":{"@xml:lang":"en","#text":"1994"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-C2OBTAUQ","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-46R7GGHL"},{"@xml:lang":"sl","#text":"Medicinski razgledi"}],"dcterms:issued":"2001","dc:creator":"Kotnik, Ana","dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:40"},{"@xml:lang":"sl","#text":"str. 45-63"}],"dc:identifier":["ISSN:0025-8121","COBISSID:13904089","URN:URN:NBN:SI:doc-C2OBTAUQ"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Medicinski razgledi"},"dc:subject":[{"@xml:lang":"en","#text":"Adverse effects"},{"@xml:lang":"en","#text":"Antibodies"},{"@xml:lang":"en","#text":"Igg"},{"@xml:lang":"en","#text":"Igm"},{"@xml:lang":"en","#text":"Immune system"},{"@xml:lang":"en","#text":"Immunology"},{"@xml:lang":"sl","#text":"imunski odziv"},{"@xml:lang":"sl","#text":"infekcije"},{"@xml:lang":"en","#text":"Pneumococcal infections"},{"@xml:lang":"sl","#text":"poškodbe"},{"@xml:lang":"en","#text":"Prevention and control"},{"@xml:lang":"en","#text":"Spleen"},{"@xml:lang":"en","#text":"Splenectomy"},{"@xml:lang":"sl","#text":"splenektomija"},{"@xml:lang":"sl","#text":"vranica"},{"@rdf:resource":"http://www.wikidata.org/entity/Q9371"}],"dcterms:temporal":{"@rdf:resource":"1994-2025"},"dc:title":{"@xml:lang":"sl","#text":"Splenektomija in imunski odziv| Splenectomy and the immune response|"},"dc:description":[{"@xml:lang":"sl","#text":"Backgrounds: Severe trauma of the spleen can be followed by excessive internalbleeding. The life of the injured person can be saved oxtly with splenectomy. Removal of the spleen reduces resistance of the patient to infections, most frequently those caused by pneumococci. The most effective way of protecting these patients is vaccination with a 23-valent pneumococcal vaccine. The aim of our research was to establish at what time after splenectomy vaccination is most effective. Different possibilities were studied: vaccination just before splenectomy, vaccination one day after and seven days after splenectomy. Our hypothesis was that vaccination just before splenectomy has the best protective effect from infection. Methods. The prospective study was carried out on thirty mice divided into six groups. Their spleens were surgically removed and they were vaccinated at different times $efore or after the operation. The first group was vaccinated, without splenectomy. The second group was vaccinated just before splenectomy, the third group 1 day after and the fourth group 7 days after surgery. The fifth group had their spleens removed without vaccination,The sixth group consisted of healthy, unvaccinated mice. During the study; the mice had their blood drawn four times. With an enzyme-linked immunosorbent assay, the changing of the amount of specific IgM and IgG antibodies directed against pneumococcal antigens was measured. The amount of precipitating antibodies in the blood serum of mice was measured with a microprecipitation capillary test. The studywas concluded with a supervised infection of mice with live pneumococci. (Abstract truncated at 2000 characters)"},{"@xml:lang":"sl","#text":"Izhodišča. Pri hudih poškodbah vranice z močno krvavitvijo lahko poškodovančevo življenje rešimo s splenektomijo. Po odstranitvi vranice je odpornost operirancev za okužbo zmanjšana. Najpogostejša je okužba s pnevmokoki. Zato moramo operirance primerno zaščititi. Najprimernejši način jepreventivno cepljenje s 23-valentnim pnevmokoknim cepivom. Zanimalo nas je, ob katerem času ima cepljenje največji učinek. Proučevali smo naslednje možnosti: cepljenje tik pred splenektomijo, cepljenje en dan po splenektomiji in cepljenje sedem dni po splenektomiji, ko si je bolnik že opomogel po operaciji. Naša hipoteza je bila, da je najustreznejše cepljenje tik pred ali takoj po splenektomiji. Metode. Prospektivno raziskavo smo izvedli na tridesetih miškah, razdeljenih v šest skupin. Operacijsko smo jim odstranili vranico in jih cepili ob različnih časih. Prvi skupini mišk vranice nismo odstranili, cepili pa smo jih s pnevrnokoknim cepivom. Drugo akupino smo cepili tik pred splenektomijo, tretjo skupino 1 dan po splenektomiji in četrtoskupino 7 dni po operaciji. Peti skupini smo odstranili vranico, ne da bi jih cepili. Šesta skupina so bile zdrave, necepljene miške. Med poskusom smo miškam štirikrat odvzeli vzorce krvi. Z encimsko-imunskim testom smo opazovali spreminjanje množine za Streptococcus pneumoniae specifičnih protiteles razredov IgM in IgG. Z metodo mikroprecipitacije v kapilari smo izmerili množino precipitacijskih za pnevmokoke specifičnih protiteles v njihovem krvnem serumu. Poskus smo zaključili z nadzorovano okužbo mišk s pnevmokoki. (Izvleček skrajšan pri 2000 znakih)"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-C2OBTAUQ","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-C2OBTAUQ"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-C2OBTAUQ/cec33b4f-cdaa-40ab-9817-7f0ef2726a36/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo Medicinski razgledi"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-C2OBTAUQ/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-C2OBTAUQ"}}}}