80 KB270 KB38 KB199820252006Götherström, AndersLidén, KerstinLinderholm, Annaštevilka:33letnik:33str. 29-37ISSN:1408-967XCOBISSID:33005922URN:URN:NBN:SI:doc-BWNOKAR3enOddelek za arheologijo Filozofske fakultete Univerze v LjubljaniDocumenta Praehistoricaarchaeologyarheologijabolezničlovekdiseaseevolucija (biologija)mezolitikneolitikposelitevprazgodovinaŠvedskavirusvirusiPushing it back| dating the CCR5-D32 bp deletion to the mesolithic in Sweden and its implications for the Meso/Neo transition|Genetic variation in the chemokine receptor gene CCR5 has received considerable scientific interest during the last few years. Protection against HIV-infection and AIDS, together with specific geographic distribution are the major reasons for the great interest in CCR5 32bp deletion. The event for the occurrence of this mutation has been postulated by coalescence dating to the 14thcen- tury, or 5000 BP. In our prehistoric Swedish samples we show that the frequency of 32pb deletion in CCR5 in the Neolithic population does not deviate from the frequency in a modern Swedish popula- tion, and that the deletion existed in Sweden already during the Mesolithic periodMed znanstveniki je bilo v zadnjih nekaj letih precej zanimanja za genetsko variacijona kemokinskem receptornem genu CCR5. Glavna razloga velikega zanimanja za zdrs 32bp na CCR5 sta zaščita proti okužbi z virusoma HIV in AIDS ter specifična geografska porazdelitev. S pomočjo 'datiranja zlitja' je bilo predpostavljeno, da se je ta mutacija pojavila v 14. stoletju AD ali pa 5000 BP. Na švedskih prazgodovinskih vzorcih pokažemo, da ni bistvenega odklona v frekvenci zdrsa 32pb na CCR5 med neolitsko in moderno švedsko populacijo in da je mutacija na Švedskem obstajala že v mezolitikuTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaUniverza v Ljubljani, Filozofska fakulteta