{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-BE7XMZOQ/c7ee494a-372f-4164-997a-6a52fcf89f70/HTML","dcterms:extent":"33 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-BE7XMZOQ/f117d53a-be27-4b27-8648-a779d697dd88/PDF","dcterms:extent":"106 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-BE7XMZOQ/d5debb2e-910b-4a47-9109-636edde92cdf/TEXT","dcterms:extent":"30 KB"}],"edm:TimeSpan":{"@rdf:about":"2005-2025","edm:begin":{"@xml:lang":"en","#text":"2005"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-BE7XMZOQ","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-8ER5ZBJN"},{"@xml:lang":"sl","#text":"Farmacevtski vestnik"}],"dcterms:issued":"2013","dc:creator":["Fic, Anja","Peterlin-Mašič, Lucija","Sollner Dolenc, Marija"],"dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:64"},{"@xml:lang":"sl","#text":"str. 57-63"}],"dc:identifier":["ISSN:0014-8229","COBISSID:3436401","URN:URN:NBN:SI:doc-BE7XMZOQ"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"biološki označevalci"},{"@xml:lang":"sl","#text":"farmakologija"},{"@xml:lang":"sl","#text":"klinična farmakologija"},{"@xml:lang":"sl","#text":"razvoj zdravil"},{"@xml:lang":"en","#text":"security"},{"@xml:lang":"sl","#text":"toksikologija"},{"@xml:lang":"sl","#text":"varnost"}],"dcterms:temporal":{"@rdf:resource":"2005-2025"},"dc:title":{"@xml:lang":"sl","#text":"Biološki označevalci in njihova uporaba pri razvoju in zagotavljanju varnosti zdravil| Biomarkers and their use in drug safety assessment|"},"dc:description":[{"@xml:lang":"sl","#text":"Biomarkers are biological indicators of health, disease or poisoning, and are now widely applicable in determining the etiology of the disease, pathophysiological, pharmacological, toxicological processes and diagnostics. In the process of research and development of new drugs we can use validated biomarkers to measure the effectiveness of therapy and predict the adverse effects of drugs. So biomarkers can increase the success rates in drug development. They can reduce the costs and shorten the drug development process, they can help in selecting the best drug candidates and they can predict efficacy and safety of the drugs and open the way for personalized medicine"},{"@xml:lang":"sl","#text":"Biološki označevalci so biološki kazalniki ali napovedniki zdravja, bolezni ali zastrupitve in so široko uporabni pri ugotavljanju etiologije bolezni, patofizioloških, farmakoloških in toksikoloških procesih ter v diagnostiki. V procesu raziskav in razvoja novih zdravil lahko s pomočjo ocenjenih bioloških označevalcev merimo učinkovitost zdravljenja ter predvidimo neželene učinke zdravil. Biološki označevalci tako pripomorejo k razvoju zdravil, znižajo stroške in skrajšajo čas razvoja zdravila, pomagajo pri izbiri najboljših kandidatov za učinkovine, bolje napovejo učinkovitost in varnost zdravila in odpirajo pot osebni medicini"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-BE7XMZOQ","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-BE7XMZOQ"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-BE7XMZOQ/f117d53a-be27-4b27-8648-a779d697dd88/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-BE7XMZOQ/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-BE7XMZOQ"}}}}