{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-BAWFQPVL/eeb25e17-a278-4792-97ea-e43409058791/PDF","dcterms:extent":"5434 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-BAWFQPVL/8779ca11-61a8-4eed-9209-90de4624c85f/TEXT","dcterms:extent":"0 KB"}],"edm:TimeSpan":{"@rdf:about":"2015-2026","edm:begin":{"@xml:lang":"en","#text":"2015"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-BAWFQPVL","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-DMTXE2ZM"},{"@xml:lang":"sl","#text":"Anali PAZU HD"}],"dcterms:issued":"2026","dc:creator":["Dugonik, Filip","Gradišnik, Lidija","Jeršič, Urška","Kač, Lejla","Maver, Tina","Zidarič, Tanja"],"dc:format":[{"@xml:lang":"sl","#text":"številka:1/2"},{"@xml:lang":"sl","#text":"letnik:15"},{"@xml:lang":"sl","#text":"str. 133-151"}],"dc:identifier":["DOI:10.18690/analipazuhd.12.1-2.133-151.2026","ISSN:2386-0219","COBISSID_HOST:288204291","URN:URN:NBN:SI:doc-BAWFQPVL"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Univerzitetna založba Univerze v Mariboru"},"dc:subject":[{"@xml:lang":"en","#text":"compounded preparations"},{"@xml:lang":"en","#text":"diclofenac sodium"},{"@xml:lang":"sl","#text":"diklofenak"},{"@xml:lang":"sl","#text":"Farmacevtska tehnologija"},{"@xml:lang":"sl","#text":"in vitro permeacija"},{"@xml:lang":"en","#text":"in vitro permeation"},{"@xml:lang":"sl","#text":"magistralni pripravki"},{"@xml:lang":"sl","#text":"propilen glikol"},{"@xml:lang":"en","#text":"propylene glycol"},{"@xml:lang":"sl","#text":"Zdravila"}],"dcterms:temporal":{"@rdf:resource":"2015-2026"},"dc:title":{"@xml:lang":"sl","#text":"Vpliv propilen glikola na permeacijo diklofenaka iz magistralnih pripravkov| in vitro študija na Strat-M4® membrani| Effect of propylene glycol on diclofenac permeation from compounded preparations| an in vitro Strat-M® membrane study|"},"dc:description":[{"@xml:lang":"sl","#text":"The aim of the study was to evaluate the effect of propylene glycol as a permeation enhancer on the permeation of diclofenac sodium from two compounded formulations through a Strat-M® synthetic membrane under in vitro conditions. Two Pentravan®-based formulations were investigated: one without enhancer and one containing 24% (w/w) propylene glycol. Permeation was assessed using Franz diffusion cells and UV-Vis spectrophotometry. The formulation containing propylene glycol showed higher diclofenac concentrations, greater cumulative permeation, and a higher fraction of permeated drug. Differences became more pronounced over time. The results confirm that propylene glycol enhances diclofenac permeation and highlight the importance of rational formulation design in topical preparations"},{"@xml:lang":"sl","#text":"Namen raziskave je bil ovrednotiti vpliv propilen glikola kot pospeševalca permeacije na prehajanje natrijevega diklofenaka iz dveh magistralnih formulacij skozi sintetično membrano Strat-M® v in vitro pogojih. Preučevani sta bili formulaciji na osnovi Pentravan® brez pospeševalca in s 24 % (m/m) propilen glikola. Permeacija je bila določena z uporabo Franzovih difuzijskih celic in UV-Vis spektrofotometrije. Formulacija z dodanim propilen glikolom je izkazovala višje koncentracije diklofenaka, večjo kumulativno permeacijo in večji delež permeirane učinkovine. Razlike so bile izrazitejše pri daljših časih. Rezultati potrjujejo, da propilen glikol izboljša permeacijo diklofenaka in poudarjajo pomen formulacijskih dejavnikov pri razvoju topičnih pripravkov"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-BAWFQPVL","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-BAWFQPVL"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-BAWFQPVL/eeb25e17-a278-4792-97ea-e43409058791/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Združenje Pomurska akademsko znanstvena unija"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-BAWFQPVL/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-BAWFQPVL"}}}}