999 KB0 KB201120252024Frangež, MatjažGlisik, Noah EmilKaiser, MašaMaver, TinaVezjak, JaroZidarič, TanjaŽnidaršič, Maticletnik:14številka:2str. 39-57DOI:10.18690/analipazu.14.2.39-57.2024COBISSID_HOST:223684355ISSN:2820-364XURN:URN:NBN:SI:doc-B7KPW9S5enUniverzitetna založba Univerze v MariboruAnali PAZUbiomimetic sensorsbiomimetični senzorjiinsulininzulinMIP sensorMIP senzormolecular imprintingmolekularno vtiskanjepolipirolpolypyrrole matrixDevelopment of biomimetic sensors to determine the functionality of in vitro cell models| Razvoj biomimetičnih senzorjev za določanje funkcionalnosti in vitro celičnih modelov|Advances in biomedical science have enabled the development of in vitro models that mimic human tissues. Non-invasive real-time monitoring of these models would provide valuable insights without disrupting the cellular environment. This study explores the use of molecularly imprinted polymers (MIPs) for this purpose, focusing on insulin and lactate as biomarkers of cellular metabolism. MIP sensors were created by electropolymerizing pyrrole around insulin or lactate templates on carbon electrodes. The sensors showed high sensitivity and selectivity, with detection ranges of 20.0–70.0 pM for insulin (LOD: 2.41 pM) and 0.5–3.0 mM for lactate. These findings highlight MIPs’ potential for personalized diagnostics and therapy monitoringTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje Pomurska akademsko znanstvena unija