{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-APNURIF6/08bc90c6-7a6e-487c-8bbb-3f7c4ebfa2fd/HTML","dcterms:extent":"67 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-APNURIF6/c9524867-2948-467e-b5ae-578432665c8a/PDF","dcterms:extent":"224 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-APNURIF6/67953c8c-a0a9-4872-b130-950c901e4ae8/TEXT","dcterms:extent":"62 KB"}],"edm:TimeSpan":{"@rdf:about":"1998-2025","edm:begin":{"@xml:lang":"en","#text":"1998"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-APNURIF6","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-KC6O72BG"},{"@xml:lang":"sl","#text":"Acta chimica slovenica"}],"dcterms:issued":"2011","dc:creator":["Božič, Borut","Lunder, Mojca","Žager, Urška"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:58"},{"@xml:lang":"sl","#text":"str. 742-754"}],"dc:identifier":["ISSN:1318-0207","COBISSID:3185777","URN:URN:NBN:SI:doc-APNURIF6"],"dc:language":"en","dc:publisher":[{"@xml:lang":"sl","#text":"Slovenian Chemical Society"},{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"}],"dc:subject":[{"@xml:lang":"sl","#text":"avto antigeni"},{"@xml:lang":"sl","#text":"avtoimunskebolezni"},{"@xml:lang":"sl","#text":"fagni zaslon"},{"@xml:lang":"sl","#text":"proteinske interakcije"},{"@xml:lang":"sl","#text":"protitelesa"}],"dcterms:temporal":{"@rdf:resource":"1998-2025"},"dc:title":{"@xml:lang":"sl","#text":"Using phage display in autoimmunity research|"},"dc:description":[{"@xml:lang":"sl","#text":"Autoimmune diseases affect approximately 3% of the population and are a significant cause of morbidity and mortality. Therefore, they are the focus of vivid research aimed at the delineation of pathology, more efficient diagnosis and therapy. Phage display is a simple methodology markedly useful in studying protein-protein interactions which are the driving forces of (patho)physiological processes, including autoimmunity. The commercially available phage display peptide libraries allow the characterization and identification of antibody-antigen and receptor-ligand binding sites, thus providing basic insight into the pathological network. Through the phage display of antibodyćs, receptorćs or ligandćs protein domains it is possible to produce various self-specificities that have already been proven useful in the therapy of autoimmune diseases. Phage antibody display libraries are able to reprint the in vivo autoimmune response which significantly facilitates structural and functional analyses of auto-reactive antibodies and assessing their role in disease pathology. The aim of this review was an overview of the versatile applications of phage display technology to determine their potential advantages in studying autoimmune diseases and to critically categorize and analyze the usefulness of phage displays towards understanding pathology and towards development of improved diagnostic tools. Above all its focus was on targeted therapy"},{"@xml:lang":"sl","#text":"Avtoimunske bolezni, ki prizadanejo približno 3 % prebivalstva, predstavljajo resen zdravstveni problem in so eden izmed pomembnih vzrokov smrtnosti. Kot take so predmet številnih raziskav, katerih cilj je razumevanje patogenih mehanizmov posamezne bolezni ter razvoj učinkovitejših diagnostičnih testov in terapevtskih pristopov. Tehnologija bakteriofagnega prikaza je zelo uporabno orodje za sistematično prou Izdelana je bila evanje interakcij med proteini. Slednje so gonilna sila (pato)fizioloških procesov, tudi avtoimunskih. S komercialno dostopnimi bakteriofagnimi predstavitvenimi knjižnicami peptidov lahko odkrivamo in ovrednotimo vezavna mesta med protitelesi in antigeni ter receptorji in ligandi, s čimer dobimo povsem osnoven, biokemijski vpogled v proteinsko mrežo mehanizma bolezni. Bakteriofagne predstavitvene knjižnice proteinov, s katerimi lahko na površinibakteriofaga izrazimo celotne domene (avtoimunskih) protiteles, receptorjev ali ligandov omogočajo razvoj bioloških zdravil uporabnih v terapiji avtoimunskih bolezni. Prav tako so bakteriofagne predstavitvene knjižnice protiteles, ki so dober približek in vivo protitelesnemu odzivu občutno olajšale proučevanje strukture in funkcije avtoimunskih protiteles ter njihove vloge v patologiji bolezni. V preglednem članku smo sistematično predstavili raznovrstne možnosti uporabe in potencialne prednosti tehnologije bakteriofagnega prikaza pri raziskovanju avtoimunskih bolezni. Članek ponuja temeljit pregled študij, v katerih so s pomočjo tehnologije bakteriofagnega prikaza raziskovali patološke mehanizme avtoimunskih bolezni in/ali razvijali nova diagnostična orodja ter usmerjene terapevtske pristope"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-APNURIF6","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-APNURIF6"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-APNURIF6/c9524867-2948-467e-b5ae-578432665c8a/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-APNURIF6/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-APNURIF6"}}}}