{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-AIP5SSU6/7b10b027-31af-4421-96a3-f70c48568ffe/PDF","dcterms:extent":"552 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-AIP5SSU6/10ae49e3-b37f-47eb-b3c6-df69d9f7b2b2/TEXT","dcterms:extent":"41 KB"}],"edm:TimeSpan":{"@rdf:about":"2005-2025","edm:begin":{"@xml:lang":"en","#text":"2005"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-AIP5SSU6","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-8ER5ZBJN"},{"@xml:lang":"sl","#text":"Farmacevtski vestnik"}],"dcterms:issued":"2022","dc:creator":"Cvikl Knehtl, Maja","dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:73"},{"@xml:lang":"sl","#text":"str. 54-63"}],"dc:identifier":["COBISSID_HOST:140694019","ISSN:2536-4316","URN:URN:NBN:SI:doc-AIP5SSU6"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"dc:subject":[{"@xml:lang":"en","#text":"antibiotics"},{"@xml:lang":"sl","#text":"Antibiotiki"},{"@xml:lang":"en","#text":"antimicrobial drugs"},{"@xml:lang":"en","#text":"critically ill patients"},{"@xml:lang":"sl","#text":"dializne metode"},{"@xml:lang":"en","#text":"dialysis techniques"},{"@xml:lang":"sl","#text":"farmakokinetično/farmakodinamični indeks"},{"@xml:lang":"sl","#text":"kritično bolni"},{"@xml:lang":"sl","#text":"ledvična funkcija"},{"@xml:lang":"en","#text":"pharmacokinetic/pharmacodynamic index"},{"@xml:lang":"sl","#text":"protimikrobna zdravila"},{"@xml:lang":"en","#text":"renal clearance"}],"dcterms:temporal":{"@rdf:resource":"2005-2025"},"dc:title":{"@xml:lang":"sl","#text":"Prilagajanje odmerjanja protimikrobnih zdravil pri kritično bolnih| Dose adjustments of antimicrobial drugs in critically ill patients|"},"dc:description":[{"@xml:lang":"sl","#text":"Dosing of antimicrobial drugs in critically ill patients remains challenging. Choosing an appropriate antimicrobial drug with effectiveness against the most likely pathogen, as well as the selection of an appropriate dosing regimen that will provide therapeutic concentration at the site of infection, is essential. When choosing a dosing regimen we should consider the phamacokinetic properties of the selected antimicrobial agents (hydrophilicity and lipophilicity, pharmacokinetic/pharmacodinamic index), the patient’s individual parameters (body weight, effect of critically illness on pharmacokinetics, kidney function – acute kidney failure, augmented renal clearance or possible application of different dialysis techniques, and extracorporeal membrane oxygenation) and susceptibility of the causative pathogen. This review article summarises factors to be considered in adjusting the dosing regimen of antimicrobial drugs in critically ill patients"},{"@xml:lang":"sl","#text":"Odmerjanje protimikrobnih zdravil pri bolnikih v intenzivni enoti predstavlja velik izziv. Izbrati je treba protimikrobno zdravilo, ki bo učinkovito proti najverjetnejšemu povzročitelju, pomembna pa je tudi izbira ustreznega odmerjanja, ki bo zagotavljalo terapevtske koncentracije na mestu okužbe. Pri izbiri odmerka je treba upoštevati lastnosti protimikrobne učinkovine (hidrofilnost ali lipofilnost, farmakokinetično/farmakodinamični indeks učinkovitosti), posebnosti bolnika (telesna masa, vpliv kritične bolezni na farmakokinetiko, ledvično delovanje – akutna ledvična odpoved, pospešena ledvična funkcija, morebitna priključitev na dializno napravo in/ali zunajtelesni krvni obtok) ter občutljivost mikroorganizma. Pregledni članek podrobneje povzema dejavnike, ki jih je treba upoštevati pri prilagajanju odmerjanja protimikrobnih zdravil pri bolnikih na intenzivni enoti"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-AIP5SSU6","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-AIP5SSU6"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-AIP5SSU6/7b10b027-31af-4421-96a3-f70c48568ffe/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-AIP5SSU6/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-AIP5SSU6"}}}}