{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-AIGG0TMB/8b861675-d3e4-4ae4-ae0c-74141c08134a/PDF","dcterms:extent":"325 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-AIGG0TMB/adfe8968-e07a-4c33-b2dc-bb18e88dd350/TEXT","dcterms:extent":"0 KB"}],"edm:TimeSpan":{"@rdf:about":"2005-2025","edm:begin":{"@xml:lang":"en","#text":"2005"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-AIGG0TMB","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-8ER5ZBJN"},{"@xml:lang":"sl","#text":"Farmacevtski vestnik"}],"dcterms:issued":"2021","dc:creator":["Brunec, Sara","Gašperlin, Mirjana"],"dc:format":[{"@xml:lang":"sl","#text":"številka:3"},{"@xml:lang":"sl","#text":"letnik:72"},{"@xml:lang":"sl","#text":"str. 173-179"}],"dc:identifier":["ISSN:0014-8229","COBISSID_HOST:70298883","URN:URN:NBN:SI:doc-AIGG0TMB"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"Debelo črevo"},{"@xml:lang":"sl","#text":"dostava zdravilnih učinkovin"},{"@xml:lang":"sl","#text":"Dostavni sistemi"},{"@xml:lang":"sl","#text":"Farmacevtske oblike"},{"@xml:lang":"sl","#text":"peroralne farmacevtske oblike"},{"@xml:lang":"sl","#text":"prebavni trakt"}],"dcterms:temporal":{"@rdf:resource":"2005-2025"},"dc:title":{"@xml:lang":"sl","#text":"Tehnološke možnosti za dostavo zdravilnih učinkovin v debelo črevo s peroralnimi farmacevtskimi oblikami| Approaches to oral colon-specific drug delivery|"},"dc:description":[{"@xml:lang":"sl","#text":"After ingestion, controlled release oral dosage forms are exposed to different physiological factors. Colon-specific drug delivery systems have to be designed to enhance drug delivery to the colon. Oral route of drug administration can be used for both the systemic drug delivery and treating local gastrointestinal diseases. This review describes the physiological, pathophysiological and pharmaceutical considerations regarding drug delivery to the colon for the oral route of administration, as well as conventional and novel drug delivery approaches"},{"@xml:lang":"sl","#text":"Farmacevtske oblike s prirejenim sproščanjem so po peroralnem vnosu na poti do debelega črevesja izpostavljene različnim dejavnikom. Za dostavo zdravilnih učinkovin v debelo črevo morajo biti dostavni sistemi zasnovani tako, da omogočijo sproščanje zdravilnih učinkovin šele v debelem črevesju, kjer lahko le-te delujejo bodisi lokalno bodisi sistemsko po absorpciji. V prispevku predstavljamo prednosti in slabosti dostave zdravilnih učinkovin v debelo črevo po peroralni poti"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-AIGG0TMB","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-AIGG0TMB"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-AIGG0TMB/8b861675-d3e4-4ae4-ae0c-74141c08134a/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-AIGG0TMB/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-AIGG0TMB"}}}}