46 KB992 KB37 KB200420252004Dovč, PeterMiloševič Berlič, Tamara11 straništevilka:2letnik:84str. 97-107ISSN:1581-9175COBISSID:1674376ISSN:1854-1941URN:URN:NBN:SI:doc-A695260ZslBiotehniška fakultetaActa agriculturae Slovenicaadipogenezafiziologijamaščobemolekularna genetikaprašičiTranskripcijsko uravnavanje adipogeneze in vloga koaktivatorja PGC-1alfa| Transcriptional control of adipogenesis and role of the coactivator PCG-1alfa|Adipogenesis is a complex proces, depending on numerous genetic and environmental factors. Study of the molecular basis of adipogenesis becomes, due to its central role in obesity and diabetes type-2 in human, more and more important also in human medicine. Adipogenesis is of central importance also for animal production, due to its impact on carcass composition, meat quality and profitability of fattening. In addition to the role of leptin and leptin receptor in adipogenesis, a new regulatory mechanism was recently discovered, which includes adaptive thermogenesis and biosynthesis of mitochondria. Important regulators of these processes are PPARy and his co-activator PGC-1alfa . In this article we describe the mechanism of adipogenesis regulation and the role of PPARy and PGC-1alfa in it. The interspecies comparison of PGC-1alfa amino sequence and possibilities for development of drugs regulating PGC-1alfa are presentedAdipogeneza je kompleksen proces, na katerega vpliva veliko število genetskih in okoljskih faktorjev. Ker je posledica prekomernega nalaganja maščob debelost, pogosto pa tudi pojav diabetesa tipa 2, postaja proučevanje molekulskih osnov adipogeneze vse bolj pomembno tudi z vidika zdravja človeka. V živalski proizvodnji proces tvorbe maščobnega tkiva pomembno vpliva na kakovost prirasta, preko porabe krme pa na ekonomičnost proizvodnje. Poleg leptina in leptinskega receptorja, ki odločilno uravnavata nalaganje maščob, je bil v zadnjem času odkrit tudi mehanizem uravnavanja tvorbe maščobnega tkiva, ki vključuje adaptivno termogenezo in biosintezo mitohondrijev. Pomembna regulatorja teh procesov sta PPAR in njegov koaktivator PGC-1alfa. V pričujočem prispevku opisujemo mehanizem uravnavanja adipogeneze in vlogo PPARy in PGC-1alfa v njem. Prikayana je tudi medvrstna primerjava aminokislinskih zaporedij PGC-1alfa in možnosti za razvoj farmacevtskih učinkovin, ki bi vplivale na izražanje PGC-1alfa TEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaUniverza v Ljubljani, Biotehniška fakulteta