284 KB18 KB200820252012Pevec, Teodorštevilka:1letnik:5str. 32-38ISSN:1855-5640COBISSID:512188984URN:URN:NBN:SI:doc-A0JHLXSVenMedicinska fakultetaActa medico-biotechnicahip fractureinfectionkolčni sklepsinbiotikisymbioticSynbiotictherapyvnetjazdravljenjezlomiVloga sinbiotikov v zmanjšanju okužb po operacijah zloma v predelu kolčnega sklepa| pilot study| pilotska študija| Role of synbiotics in reducing postoperative infections in patients with hip fracture|Purpose: Despite the development of surgical methods, infections continue to be serious postoperative complications. Probiotics have been shown to be effective in reducing the prevalence of infections. We explored the effectiveness of probiotics in reducing the prevalence of infections in subjects undergoing surgery for hip fractures. Methods: Fifty-one patients admitted for surgical treatment of hip fractures were divided randomly into two groups: Synbiotic 2000 Forte and placebo. The occurrence of infection was closely observed upon hospital admission until the fifth postoperative day using, among other parameters, the C-reactive protein (CRP) level. Additionally, the patients' tolerance to Synbiotic 2000 Forte was established using subjective (self-reported problems) and objective means. Results: Infection was confirmed in 4 patients in each group. Urinary tract infection was noted in 7 subjects and a local wound infection in 1 patient. No differences were found in CRP levels upon hospital admission and the fifth postoperative day. Tolerance to Synbiotic 2000 Forte was lower in patients undergoing placebo treatment. Conclusion: Synbiotic 2000 Forte did not reduce the number of postoperative infections. Further studies are needed to confirm these findingsNamen: Število bolnikov z zlomom v predelu kolčnega sklepa narašča skupaj s staranjem prebivalstva. Okužbe, ki nastopajo po samem posegu, tako sistemske kot lokalne, pomembno vplivajo na uspeh operacije. Uporaba probiotikov dokazano zmanjšuje okužbe, zato nas zanima, ali lahko uporaba le-teh zmanjšuj eokužbe tudi v skupini bolnikov po operacijah zlomov v predelu kolčnega sklepa. Metode: Opravili smo dvojno slepo randomizirano študijo pri51 bolnikih. Ob sprejemu so dobili ali preparat SYNBIOTIK 2000 FORTE ali placebo. Opazovali smo nastanek okužb, merili vrednost C reaktivnega proteinain opazovali, kako so bolniki prenašali uživanje preparata. Rezultati: Okužbe so se pojavile prištirih bolnikih v vsaki skupini. Pri sedmih bolnikih je šlo za uroinfekt in pri enem za okužbo rane Zaključek: V raziskavi nismo dokazali vpliva SYNBIOTICA 2000 FORTE na zmanjševanje okužb pooperacijah zlomov v predelu kolčnega sklepa. Število bolnikov bi moralo bitivečje, skupina bi morala biti manj heterogena glede na stopnjo ogroženosti bolnikov pred operacijo in na čas med poškodbo in operacijoTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaUniverza v Mariboru, Medicinska fakulteta