{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-9RCG33ZO/f1306810-b3c8-439f-a385-daec676b19aa/PDF","dcterms:extent":"30138 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-9RCG33ZO/409af794-76d8-4c8c-9c12-8b8851a75dfe/TEXT","dcterms:extent":"65 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-9RCG33ZO","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:SPR-WQVGMCSC"},{"@xml:lang":"sl","#text":"Acta dermatovenerologica Alpina, Pannonica et Adriatica"}],"dcterms:issued":"2023","dc:creator":["Abecasis, Ana B","Lunar, Maja M.","Mlakar, Jana","Pečavar, Blaž","Poljak, Mario","Tomažič, Janez","Turel, Gabriele","Vandamme, Anne-Mieke","Vovko, Tomaž"],"dc:contributor":"Poljak, Mario","dc:format":[{"@xml:lang":"sl","#text":"letnik:32"},{"@xml:lang":"sl","#text":"številka:iss. 3"},{"@xml:lang":"sl","#text":"str. 99-110"}],"dc:identifier":["DOI:10.15570/actaapa.2023.20","ISSN:1318-4458","COBISSID_HOST:167503619","URN:URN:NBN:SI:doc-9RCG33ZO"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovene Welding Society"},"dc:subject":[{"@xml:lang":"sl","#text":"Central Europe"},{"@xml:lang":"en","#text":"filogenija"},{"@xml:lang":"sl","#text":"HIV-1"},{"@xml:lang":"sl","#text":"molecular epidemiology"},{"@xml:lang":"en","#text":"molekularna epidemiologija"},{"@xml:lang":"en","#text":"ne-B podtip"},{"@xml:lang":"sl","#text":"non-B subtype"},{"@xml:lang":"sl","#text":"phylogeny"},{"@xml:lang":"en","#text":"podtipiziranje"},{"@xml:lang":"en","#text":"srednja Evropa"},{"@xml:lang":"sl","#text":"subtyping"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"HIV-1 subtype diversity and phylogenetic insight into non-B subtype transmission in Slovenia, 1989-2013|"},"dc:description":{"@xml:lang":"sl","#text":"Introduction: Disease progression, drug resistance mutations, and treatment strategies may vary by HIV-1 subtype. This study determined HIV-1 subtypes circulating in Slovenia, a Central European country with an HIV-1 epidemic driven by men who have sex with men, focusing on molecular epidemiology of non-B subtypes. Methods: A total of 367 HIV-1 sequences were included. Subtype was assigned by employing eight different HIV subtyping tools coupled with maximum likelihood phylogenetic analyses. Results: The subtyping tools COMET, jpHMM, and REGA 3.0 exhibited the best performance on the dataset studied. Phylogenetic analyses showed a 14.7% prevalence of non-B subtypes, with subtype A detected most frequently (4.9%), followed by CRF02_AG (2.4%), subtype C (1.1%), subtypes D, G, and CRF01_AE (0.8% each), and subtypes F and CRF22_01A1 (0.3% each). A subtype could not be assigned to 12 sequences (3.3%), indicating potential unique recombinant forms. Non-B subtypes were significantly associated with a heterosexual route of transmission and infection acquired in Eastern Europe, Africa, or Asia. Conclusions: In a country where subtype B is predominant, non-B subtypes were observed in one out of seven patients, a nonnegligible proportion, which underlines the importance of systematic surveillance of HIV subtype diversity and the corresponding molecular epidemiology"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-9RCG33ZO","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-9RCG33ZO"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-9RCG33ZO/f1306810-b3c8-439f-a385-daec676b19aa/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Združenje slovenskih dermatovenerologov"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-9RCG33ZO/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-9RCG33ZO"}}}}